Acetaminophen (APAP) poisoning is the most common drug intoxication, which often leads to acute liver failure (ALF). In this study, the effects of different doses of APAP on aminotransferases (AST and ALT) and liver pathological lesions were assessed in young rats. 32 male albino Wistar rats were randomly selected and divided into eight groups. In case groups, three groups after one hour, and 3...

Presenter: Diamantis Tsilimigras MD | The Ohio State University Background: Tumor necrosis has been associated with unfavorable prognosis among patients hepatocellular carcinoma and hilar cholangiocarcinoma. prognostic impact of tumor undergoing resection for intrahepatic cholangiocarcinoma (ICC) remains ill-defined. Methods: Patients who underwent curative-intent ICC between 2000-2017 were ide...

OBJECTIVE To determine the degree of tumor necrosis in surgical specimens of hepatocellular carcinomas treated with microspheres preloaded with doxorubicin and to analyze the relationship between the degree of necrosis and a) morphologic factors and b) imaging biomarkers. MATERIAL AND METHODS We studied the livers of 21 patients who had undergone selective arterial chemoembolization with DC b...

Pre-eclampsia complicated by deep jaundice occurred in a previously healthy primigravida. The main aetiological factor was disseminated intravascular coagulation; this caused both haemolysis and liver cell necrosis. Liver biopsy showed fibrin thrombi in the capillaries with microhaemorrhages and loss of periportal liver cells. The jaundice was attributed to both haemolytic and hepatocellular pr...

A previously unknown disease which has spread among broiler poultry farms in Pakistan, attacks well-growing chicks at 3-5 weeks of age, with 30 to 60% mortality. At necropsy, the most prominent lesion is hydropericardium. Lungs are congested and oedematous, and liver and kidneys are pale and swollen. Histologically, there was necrosis and severe vascular changes in the heart as well as congesti...

A review is made of the various histological lesions observed in hepatitis B virus-related liver diseases, including different forms of acute and chronic hepatitis, cirrhosis, and hepatocellular carcinoma. The elementary lesions discussed include acidophil necrosis (apoptosis), confluent lytic necrosis in its different patterns, piecemeal necrosis, focal necrosis, and dysplastic hepatocytes. Th...

Neuroendocrine neoplasms (NENs) predominantly arise within the intestinal tract, pancreas, and lung, but may develop in various organs commonly metastasize, especially to liver. Cross-sectional imaging (ultrasound, computed tomography, magnetic resonance imaging) play a central role detection, characterization, management, follow-up of NENs. Imaging features tumors significantly vary as per sit...

Plumbum exposure is known can induce excessive production of Reactive Oxygen Species (R.O.S.) and cause oxidative stress on the cell. Oxidative disorders in body's organs, one which liver organ. The study aims to determine effect giving red fruit oil as a protection against plumbum at rate degeneration cell necrosis liver. Red contains antioxidant compounds beta carotene tocopherol that functio...

Excessive acetaminophen (APAP) use is one of the most common causes of acute liver failure. Various types of cell death in the damaged liver are linked to APAP-induced hepatotoxicity, and, of these, necrotic cell death of hepatocytes has been shown to be involved in disease pathogenesis. Until recently, necrosis was commonly considered to be a random and unregulated form of cell death; however,...