The hepatoprotective activity of a fraction of the leaf extract of A.indica against carbon tetrachloride : liquid paraffin (1:1) induced liver damage in rats at doses of 100 mg/kg and 200 mg/kg was evaluated. A significant dose dependent hepatoprotective activity was evidenced by lowering of the elevated levels of glutamate oxaloacetate transaminase (GOT), glutamate pyruvate transaminase (GPT),...

Levels of serum alkaline phosphatase (ALP) and the hepatic enzyme ALT are used to monitor medication toxicity [1]. ALP is important in osteoarticular processes because, excluding the liver, the highest concentrations of this enzyme can be found in the bone [1, 2]. High doses of clindamycin and first-generation cephalosporins have cytotoxic effects against osteoblasts in vitro [3-5]. The serum c...

The fresh water field crab, Spiralothelphusa hydrodroma is an important food source in parts of South India. The impact of cypermethrin on the variations in the enzyme activity of gills and hemolymph of the experimental female crab S. hydrodroma was carried out. The toxicity of the cypermethrin on the crab was estimated using LC50. Quantitative enzymatic studies of lactate dehydrogenase (LDH), ...

BACKGROUND Alkaline phosphatase (ALP) is a widely used marker for skeletal and hepatobiliary disorders, but its activity is also increased in atherosclerosis and peripheral vascular disease. It is an inflammatory marker like C-reactive protein (CRP). We therefore analyzed its relationship with CRP in the United States National Health and Nutrition Examination Survey (NHANES) 2005-2006. METHOD...

PURPOSE Serum alkaline phosphatase (ALP) level is the most valid marker of bone formation. Precocious puberty (PP) in girls is characterized by early growth acceleration. The aim of this study was to determine whether serum ALP levels differ between girls with PP and those with normal puberty, and whether ALP level varies with age or Tanner stage. METHODS This retrospective study included gir...

BACKGROUND Xiaochaihu Decoction (XCHD) prevents hepatocarcinogenesis in association with inhibition of oxidative stress. However, alkaline phosphatase (ALP) activity, lipopolysaccharides (LPS)-catecholamines (CA) interactions in gut, liver and brain may play an important role in the status of oxidative stress. This study was to assess whether XCHD attenuates the vicious circle between oxidative...

We evaluated the protective effects of soy isoflavones (SIF) against osteoporosis in middle-aged ovariectomized (OVX) mice. SIF (30 mg/kg or 60 mg/kg) or 17beta-estradiol (E(2)) was administered to OVX mice for 4 months after bilateral ovariectomy. We observed the biochemical markers of bone turnover, e.g., alkaline phosphatase (ALP) and tartrate-resistant acid phosphatase (TRAP), in serum. We ...

Aphanamixis polystachya is a traditional medicinal plant of the Meliaceae family in India. A crude ethanolic extract of the leaf of this plant shows a beneficial effect on toxic liver injury. Its antihepatotoxic activity was evaluated on carbon tetrachloride (CCl4)-induced liver injury in a rat model. The assessment of hepatoprotective activity was evaluated by measuring the activities of aspar...

A useful laboratory test for the differentiation of liver, bone, and intestinal alkaline phosphatase (ALP) isoenzymes in serum is presented. Electrophoresis in polyacrylamide gel is performed with untreated serum as well as with serum incubated at 56 degrees C for 10 min. The heating step denatures bone isoenzyme which may obscure the liver ALP band when present in large amounts. Visualization ...

In this study, changes in the activities of serum total and prostatic acid phosphatase (TACP and PACP, respectively), alkaline phosphatase (ALP), gamma( )-glutamyltransferase (GGT) and testosterone level were assessed in male rats exposed wholly to 17.8±2.6cm hrkgm day of gasoline vapours (8 hours daily, 6 days/week) for 20 weeks in exposure chambers. The results showed that exposure to gasolin...