Although recent technical advances have established the feasibility of force measurements in single cardiac myocytes, the physiological relevance of this model has not been fully evaluated. We measured active force and sarcomere length in single rabbit left ventricular myocytes and compared their physiological responses to changes in stimulus interval, calcium concentration and sarcomere length...

INTRODUCTION The myocardial response to acute stretch consists of a two-phase increase in contractility: an acute increase by the Frank-Starling mechanism and a gradual and time-dependent increase in force generated known as the slow force response (SFR). The SFR is actively modulated by different signaling pathways, but the role of protein kinase G (PKG) signaling is unknown. In this study we ...

The polarity of solutions of LiCIO 4 in acetic acid has been investigated. However, polarity scal4s based on light absorption, e.g. the ~-scale, are interfered by aggregation phenomena of the used ~olvatochromic dyes, whereas solvatochromic fluorescent dyes give proper results. Salt containing solvents are used in mechanistic studies of solvolytic displacement reactions. The special salt effect...

Monocarboxylate Transporter 1 (MCTl) mediates the transport of the main fraction of lactate across the sarcolemma. A common polymorphic MCTl variant has been identified, but its role in high intensity exercise performance has not been defined. We investigated the influence of MCTl A1470T polymorphism (rsl049434) on lactate accumulation after high intensity circuit training. Ten men aged 20-26 p...

The density, size composition and growth of Nephrops norvegicus were examined at six sites in part of the Firth of Clyde, SW Scotland, between 1990 and 1992. Sampling was carried out using small mesh trawls and by an underwater television camera. The growth of male Nephrops at each site was investigated by analysis of length–frequency distributions using the computer program ‘‘Multifan’’. Estim...

In a "physiologically sequenced" contraction (PSC), which loads the isolated muscle preparation in a manner which approximates that of the intact heart, isometric relaxation precedes isotonic relaxation and occurs at minimum ("end-systolic") length. We studied the effects of inital muscle length, load, temperature, calcium, and isoproterenol on the isometric relaxation phase of physiologically ...

Through joined two sensitive methods solvation and cloud point extraction separated and determined micro amount of Ce(III) from aqueous solutions by using organic reagent 2,4-Dimethyl pentan-3-one (2,4-DMP) as extractant and non-ionic surfactant 1% TritonX-100 , the experimental study shows the solvation species of Ce+3 extracted into cloud point layer (CPL) have a wavelength for maximum absorb...

In the intact heart, there are simultaneous changes in stress and length throughout the cardiac cycle. In a recently developed digital control system for experiments on isolated papillary muscles from rabbit right ventricle, we included a controlled auxotonic twitch. This twitch allowed proportional changes in stress and length, as if the muscle was acting against an ideal spring. The auxotonic...

It is well known that in the majority of cases the problem of preemptive task scheduling on m parallel identical processors with the objective of minimizing makespan can be solved in polynomial time. For example, for tree-like precedence constraints the algorithm of Muntz and Co€man can be applied. In this paper, this problem is generalized to cover the case of parallel processors which are ava...

A joint research group was formed to evaluate the effects of flooring and ceiling choices on controlling “corridor activity noise” in an occupied hospital. Beside noise control within the corridors, the sound absorption also played an important role in isolating sound from room to room and from nurses‟ station to patient rooms. In the present study, noise levels (recorded as percentile level Ln...