Breast cancer is now the most common cancer diagnosedworldwide. There is substantial evidence that 5 years of treatment with chemopreventive agents, such as tamoxifen, raloxifene, and exemestane, can reduce the incidence of hormone-positive cancers in high-risk women. Nevertheless, the uptake of these agents has been poor, even in women with atypical hyperplasia and lobular carcinoma in situ (L...

Sponsored by 2 Tomosynthesis enables definitive identification of unsuspected lesions in multifocal or multicentric cancers, decreasing the need for second-look US and post-MRI biopsy 4 Tomosynthesis finds a spiculated mass not seen in traditional 2D mammogram 6 Tomosynthesis significantly reduces screening callback rates and increases our ability to detect early cancers 8 Diagnosis of US/MRI-o...

Introduction. Most common metastasis sites of breast cancer are the lungs, bones, liver, and brain, whereas uterine involvement by metastatic breast disease is rare. Metastatic carcinoma of the uterus usually originates from other genital sites, most commonly being from the ovaries. Invasive lobular carcinoma spreads to gynecologic organs more frequently than invasive ductal carcinoma. Case Rep...

AIMS The aim of this study was to compare breast cancer specific survival (BCSS) for invasive lobular carcinoma (ILC) and invasive ductal carcinoma (IDC) and, further, to evaluate critically the prognostic value of histopathological grading of ILC and examine E-cadherin as a prognostic marker in ILC. METHODS AND RESULTS The study comprised 116 lobular and 611 ductal breast carcinomas occurrin...

BACKGROUND The role of fulvestrant in the management of intestinal obstruction associated with lobular carcinoma has not been specifically described. CASE PRESENTATION Herein we present two cases where fulvestrant, as the only available parenteral endocrine agent for postmenopausal advanced breast cancer has the opportunity to provide a means to initiate treatment in those patients who presen...

Invasive lobular carcinoma of breast is well known to be able to metastasise to unusual places, including the gastrointestinal and gynaecological tracts. However, it is very unusual for breast cancer to present in an ovarian Brenner tumour. This case highlights the diagnostic difficulties of patients presenting with unilateral ovarian masses, and the merits of thorough histological assessment o...

We experienced a very rare case of occult breast lobular carcinoma with numerous circulating tumor cells in peripheral blood. The diagnosis was very difficult because there were no symptoms of breast cancer and the preceding chief complaints such as general fatigue and weight loss or abnormality of peripheral blood findings were suggestive of a hematological disease. We could make a correct dia...

Sclerosing adenosis (SA) is a proliferative lesion that is commonly found in benign breast biopsies. The identification of increased cancer risk for patients with SA suggests that tumorigenic alterations may be associated with the pathogenesis of this lesion. We here report a case of old female who presented with a breast lump. Trucut biopsy proved it to be a case of sclerosing adenosis, later ...

Lobular carcinoma in situ (LCIS) and atypical lobular hyperplasia (ALH) of the breast are cytologically similar breast lesions that reportedly carry different relative risks of subsequent development of invasive car cinoma. They are frequently multifocal and bilateral. We have identified the chromosomal copy number changes in 31 LCIS and 14 ALH lesions from 28 cases and also the 7 invasive carc...

BACKGROUND Invasive lobular carcinoma (ILC) is the second most common histological type of invasive breast carcinoma, preceded only by infiltrating ductal carcinoma, which has clinical, biological and molecular distinctions. These distinctions imply a different metastatic behavior between the histology of these 2 types of breast cancer. CASE PRESENTATION We report the case of a 51-year-old wo...