Topical drug dosage forms such as ointments and creams can be easily removed through wetting, movement and contact. The new bioadhesive formulations with enhanced local anesthetic effects are needed for topical administration. The adhesive capacity of hydroxypropyl methylcellulose (HPMC) was determined by measuring the maximum detachment force and the adhesion work with an auto peeling test...

OBJECTIVES To evaluate the clinical pain during local anesthetic injection using such intra-oral device. STUDY DESIGN A comparative split-mouth clinical study to evaluate clinical pain was conducted among the subjects who required bilateral local anesthetic intra-oral injections. RESULTS A total of 99 subjects participated in the study out of which 39 were female. A total of 256 local anest...

who compared postoperative pain after traditional and single‑incision laparoscopic cholecystectomy (SILC), it was showed that SILC resulted in a slightly less immediate postoperative pain, but pain scores at 24 hours, 7 days, and 1–6 months after surgery were not different between the two operations. Many things of this study were well done. The authors used a double‑blinded, randomized, and co...

BACKGROUND Use of Mayfield clamps is associated with potentially hazardous hemodynamic effects. Use of local anesthetic infiltration has yielded varying results in blunting of this response. The authors' objective was to study the effect of lidocaine with adrenaline infiltration at Mayfield pin sites on hemodynamic response in comparison with no intervention. METHODS This was a prospective co...

BACKGROUND Synovial fluid culture (SFC) is recommended as one of the major diagnostic criteria by the Musculoskeletal Infection Society (MSIS) for diagnosing periprosthetic joint infection (PJI). Local anesthetic agents are used for anesthesia and analgesia in some clinical settings to relieve pain. As a local anesthetic, lidocaine is safely used in arthrocentesis to obtain synovial fluid. The ...

cision is closely associated with postoperative wound pain [9]. The single umbilical incisions reported in other studies typically reached lengths of 15 to 20 mm. Although postoperative pain has not been a major concern since the introduction of the routine laparoscopic cholecystectomy (LC), supporters of a single-incision LC (SILC) advocate the hypothesis that a reduction in the number of inci...

Local anesthetic toxicity remains a clinical concern when performing regional anesthesia. Because signs and symptoms of toxicity may not appear for 20 to 30 minutes after administration of local anesthetic, vigilance is crucial. When signs and symptoms of local anesthetic toxicity appear, traditional standards mandate resuscitative measures, including maintenance of oxygenation, elimination of ...

BACKGROUND/AIM To compare local infiltration anesthesia (LIA) and peripheral nerve block (PNB) in repairing hand lacerations. MATERIALS AND METHODS This prospective study was designed as a randomized, controlled, unblinded trial. Fifty four patients with hand lacerations were included in the study. While 23 of these patients had LIA, PNB was performed in the remaining 31 patients. Lidocaine h...

Local anesthetic systemic toxicity (LAST) is a rare but avoidable consequence of local anesthetic overdose. This article will review the mechanism of action of local anesthetic toxicity and the signs and symptoms of LAST. Due to physiologic and anatomic differences between children and adults, LAST occurs more frequently in children; particularly when 3% mepivacaine is administered. The calcula...