Alopecia areata (AA) is an autoimmune disease due to T cell attack of observation made in a special patient is complemented with mechanisthe hair follicles and breakdown of their immune privilege resulting in transient non-scarring hair loss which may last from weeks to decades and which presents an enormous psychological burden. As so far no FDA approved successful treatments for AA are availa...

Alopecia areata (AAR) and androgenetic alopecia (AGA) are two major forms of alopecia based on altered hair growth condition. In general, the cell cycle is regulated by several mechanisms including the stem cell factor/c-kit signaling. To assess a role for stem cell activity in alopecia, we performed histopathological, immunohistochemical, and semiquantitative analyses of c-kit as well as Ki-67...

Alopecia areata is a chronic relapsing autoimmune disease characterized by local or diffuse non-scarring hair loss. Statistically, 0.2% of people worldwide are affected alopecia and 1.7% were diagnosed with it at some point in life. The incidence children has been rapidly increasing recent years.
 main role pathogenesis belongs to the loss immune privilege due influence genetics various ex...

Objective: To compare the histopathological findings in horizontal and vertical sections in cases of alopecia with their clinicopathological correlation. Materials and methods: A study of 50 patients was conducted to study the histopathological findings in horizontal and vertical sections in cases of alopecia along with their clinicopathological correlation. Results: In our study, major causes ...

Alopecia areata (AA) is a heterogeneous disease characterized by nonscarring hair loss on the scalp or any hair-bearing surface. A wide range of clinical presentations can occur, from a single patch of hair loss to complete loss of hair on the scalp (alopecia totalis, AT) or over the entire body (alopecia universalis, AU). The cause of AA is unknown although most evidence supports the hypothesi...

Abnormal hair development and regeneration occurs in some skin diseases, including lymphomas when hair follicles are eliminated. Otherwise, neoplastic cells, both malignant and benign, local occurring and metastatic, can cause alopecia of the scalp. In lymphomas alopecia can develop due to direct infiltration by the disease, or it may be a secondary or paraneoplastic manifestation. Total -body ...

Osteopontin (OPN) is a multifunctional glycophosphoprotein secreted by many cell types, including osteoblasts, lymphocites, macrophages, epithelial cells, and vascular smooth muscle cells. It has been implicated in many physiological and pathological processes, such as cell-mediated immunity, inflammation, cell survival, and tumor invasion and metastasis. Osteopontin has multiple emerging roles...

OBJECTIVE To compare the mean Vitamin D level in patients with alopecia areata (AA) with age and gender controlled matched healthy controls. STUDY DESIGN Case-control study. PLACE AND DURATION OF STUDY Dermatology OPD, JPMC, from October 2014 to March 2015. METHODOLOGY All the patients diagnosed of alopecia areata by a trained dermatologist were selected. Controls were age and gender matc...

Alopecia areata (AA) is a common and distressing condition in populations worldwide. The course of this condition is unpredictable and remains elusive. Patients with AA have a negative appraisal of their self-image, resulting in a demand for any effective treatment options. Hair transplantation might be considered for those patients who have exhausted standard clinical therapies for a period of...

Androgenetic alopecia is a fairly common disorder which causes serious aesthetic and psychological problems. The paper discusses the etiology, diagnostics and possible treatment of androgenetic alopecia in women. Preparations for both general and external use in treatment of this dermatosis have been presented herein.