Phospholipidosis (PLD) is characterized by the excessive intracellular accumulation of phospholipids. It is well established that a large number of cationic amphiphilic drugs have the potential to induce PLD. In the present study, we describe two facile in vitro methods to determine the PLD-inducing potential of a molecule. The first approach is based on a recent study by (Sawada et al., 2005, ...

The present study aimed to establish whether anxiety and depression in nasal polyposis play a role in genesis of the disease, or are a consequence of symptoms. Anxiety levels were evaluated in state and trait forms, and depression, in 30 consecutive patients presenting nasal polyposis before and after effective 7 months' medical treatment with nasal mometasone, loratadine and montelukast. Befor...

Laser electrospray mass spectrometry (LEMS) is demonstrated for pharmaceutical samples at atmospheric pressure. A nonresonant, femtosecond duration laser pulse vaporizes native samples at atmospheric pressure into an electrospray plume for ionization with subsequent transfer into a time-of-flight mass spectrometer. The active ingredients in pharmaceutical tablets were detected in the presence o...

Story From the Front Lines An83-year-oldwomanwith a history of atrial fibrillation and congestive heart failure was admitted to the hospital after presenting with lightheadedness and palpitations secondary to atrial fibrillation with rapid ventricular response. This was her third admission for atrial fibrillationwithuncontrolledheartrate inthepast6months.Pharmacy records indicated she had not r...

In this review, we compare and contrast the clinical pharmacology, efficacy, and safety of first-generation H1 antihistamines and second-generation H1 antihistamines. First-generation H1 antihistamines cross the blood-brain barrier, and in usual doses, they potentially cause sedation and impair cognitive function and psychomotor performance. These medications, some of which have been in use for...

Fractional calculus; Conformable operators; Calculus on time scales Abstract A conformable time-scale fractional calculus of order a 2 0; 1 is introduced. The basic tools for fractional differentiation and fractional integration are then developed. The Hilger timescale calculus is obtained as a particular case, by choosing a 1⁄4 1. a 2015 The Authors. Production and hosting by Elsevier B.V. on ...

No abstract available. Article truncated after 150 words. History of Present Illness: A 57-year-old woman with history bone disease presented a 3-day cough thick yellow phlegm and progressive shortness breath. fever, chest pain or abdominal was noted. In the emergency department, she had SpO2 55% on room air, then 90% 15L NRB. Past Medical History/Social History/Family • Bone since birth Asthma...

BACKGROUND The main objective of this randomized, double-blind, parallel-group, comparative study was to assess the efficacy and safety of rupatadine 10 mg (R10) and 20 mg (R20) administered once-daily for two weeks compared with those of loratadine 10 mg (L10) in the treatment of seasonal allergic rhinitis (SAR). METHODS A total of 339 SAR patients were randomized to receive R20 (111 patient...