Abstract Background The concept of bioenhancer comes from Ayurveda. Many ways have been documented in the literature to boost bioavailability poorly bioavailable medications, and one most recent techniques is use enhancers. Main body abstract Herbal bioenhancers are a choice modern medicine because their easy absorption, safety, lack side effects. They also reduce drug toxicity, decrease treatm...

Introduction: Correlation between circulating sex steroid levels and breast cancer has been controversial, with measurement of free, or bioavailable hormone rarely available. Salivary hormone levels represent the bioavailable fraction. We aimed to assess correlation between salivary sex steroid levels and breast cancer prevalence. Methods: Salivary hormone levels of testosterone (T), Estradiol ...

Andropause is a syndrome described in aging males, is composed of a constellation of physical, sexual, and emotional symptoms, and is thought to be related to declining concentrations of serum testosterone. Numerous studies of testosterone replacement therapy in elderly hypogonadal males have documented the physical benefits of such treatment, but have failed to assess cognition, psychological ...

Three chick assays were conducted to determine a bioavailable Zn requirement and to establish a Zn relative bioavailability (RBV) value for tetrabasic Zn chloride [TBZC, i.e., Zn5Cl2(OH)8]. In Assay 1, 8-d-old chicks were fed a Zn-deficient soy concentrate diet (8.8 mg/kg bioavailable Zn) supplemented with 0, 5.81, 10.81, 15.10, and 20.25 mg Zn/kg from ZnSO4.7H2O for 14 d to establish a linear ...

OBJECTIVE The role of vitamin D in cardiovascular health remains debated as results have been inconsistent. Previous studies have not considered the bioavailability of 25-hydroxy vitamin D [25(OH)D]. Objectives of our study were to investigate the association between serum concentrations of total, free and bioavailable 25(OH)D and independent predictors of cardiovascular risk such as flow media...

BACKGROUND We examined if the reduced risk of breast cancer events seen among women without baseline hot flash symptoms in the Women's Healthy Eating and Living (WHEL) dietary intervention trial was related to changes in sex hormone concentrations. METHODS Baseline and year one concentrations of total and bioavailable estradiol, and testosterone and sex hormone-binding globulin (SHBG) were co...

Changes in nutrient bioavailability due to increased loading of dissolved organic matter (DOM) may impact boreal freshwaters. Yet, the relative carbon (C), nitrogen (N), and phosphorus (P) associated with terrestrial DOM remains poorly understood. We applied short-term bioassays natural bacterial inocula determine seasonal variation bioavailable pools from four headwater streams northern Sweden...

Objective: In the present research work, aim was to prepare pH trigged in-situ ocular gel of Cetirizine Hydrochloride (CTZ) improve its local bioavailability at eye surface. Methods: CTZ prepared by pH-trigged method. In-situ a pH-sensitive gelling agent (Carbomer) with one-viscosity builder polymer (HPMC E4M). All formulation evaluated for appearance, pH, viscosity different capacity, % drug c...

Previous reports found that some fluoride-containing dentifrices do not release effective concentrations of fluoride during brushing. Failure to release fluoride can be due to dentifrice matrix components that interfere with the solubilization of the fluoride salts during brushing. A new generation of dentifrices has the capability to precipitate beneficial fluoride salts during tooth brushing....

Epidemiological investigation have suggested that there is a significantly inverse association between circulating 25-hydroxyvitamin D (25(OH)D) and the risk for developing colorectal cancer (CRC) in humans. However, little is known about the role of vitamin D binding protein (VDBP) in colorectal carcinogenesis. Blood samples were collected from 212 CRC patients and 212 controls matched with ag...