BACKGROUND Topical creams with capsaicin are used to treat pain from a wide range of chronic conditions including neuropathic pain. Following application to the skin capsaicin causes enhanced sensitivity to noxious stimuli, followed by a period with reduced sensitivity and, after repeated applications, persistent desensitisation. There is uncertainty about the efficacy and tolerability of capsa...

Darunavir is an efficacious drug; however, pharmacokinetic variability has been reported. The objective of this study was to find predisposing factors for low darunavir plasma concentrations in patients starting the once- or twice-daily dosage. Darunavir plasma concentrations from January 2010 till December 2014 of human immunodeficiency virus-infected individuals treated in the outpatient clin...

[1] The concentration Nd of cloud droplets in marine low clouds is a primary determinant of their ability to reflect sunlight and modulates their ability to precipitate. Previous studies have focused upon aerosol source variability as the key driver of variability in Nd. Here, we use a highly simplified aerosol budget model to examine the impact of precipitation on Nd. This model considers: pre...

The static and dynamic response associated with a low concentration, x, of static defects in a Heisenberg antiferromagnet at zero temperature is analyzed within linearized spin‐wave theory. We obtain the dispersion relation for long‐wavelength spin waves in the form ω(q )= c ( x ) q + iγ( x ) q τ. Our results for c(x) agree with previous work, and in particular give c(x) = c(0)[1 + αx + O(x 2)]...

From out data bank, we analyzed results for thyroxine concentration in blood samples spotted on filter paper from different age groups (one to nine days postpartum) of our low-birth-weight and normal population. It was significantly lower in the low-birth-weight infants in almost all the age groups, and in both groups it significantly declined after postnatal day 5. The influence of weight is m...

Only 17.5 % of all Indian homes use LPG as their primary cooking fuel, with 90 % of rural households dependent on some form of biomass. To improve the quality of life of such a large number of people, it is imperative that clean and renewable alternatives are provided for cooking. This paper presents one such. An ethanol stove running on 50 % ethanol-water mixture has been developed at Nimbkar ...

Carboxyhemoglobin alters the oxyhemoglobin dissociation curve in such a manner that oxygen is released to the tissues with great difficulty and at a lower oxygen tension. The known effects on heart and brain of breathing low concentrations of carbon monoxide are primarily related to this leftward shift and perhaps also to its combination with myoglobin and certain iron-contain­ ing enzymes. Hem...

To assess the efficacy and tolerability of topically applied low-concentration (less than 1%) capsaicin for treating chronic neuropathic pain in adults.

Bisphenol A (BPA) acts as xenoestrogen and has a great impact on disorders of human reproductive system. However, the mechanism through which BPA can affect human testicular function remains to be identified. GPR30 is a novel membrane estrogen receptor with high-affinity and low-capacity binding to estrogens. We demonstrated that estrogen receptor α (ERα), estrogen receptor β (ERβ) as well as G...

AIM To test the effect of a noncaustic concentration of peracetic acid (PAA) in a standardized smear layer model. METHODOLOGY The smear layer dissolution kinetics of 0.5% PAA on human dentine were compared to those of 2.25% PAA and 17% ethylenediaminetetraacetic acid (EDTA) solutions. Coronal dentine discs were prepared from six human maxillary molars. A standardized smear layer was produced ...