In order to avoid using cytotoxic drugs and to minimize prednisolone side effects in frequent relapsing or steroid-dependent idiopathic nephrotic syndrome, 35 patients, 3 to 15 (mean= 8.1) years of age, were studied. While in remission for at least 6 weeks, the dose of prednisolone was reduced to 0.1-0.37 (mean= 0.23) mg/kg/day as a single dose for 12 to 72 (mean= 27.6) months. It was follo...

introduction: cyclophosphamide (cp) is used for the treatment of various cancers. in spite of its therapeutic importance, a wide range of adverse effects such as reproductive toxicity has been observed following the administration of this drug in human and experimental animals. in the current study, we have investigated the adverse effects of cp on morphology and histology of testis rats. metho...

forty-six cases of patients suffering from acne cystica (conglobata) were treated by low-dose dapsone plus folic acid (1 mg/day). this study has been performed on patients that had no response to other treatments. several essential and careful tests and examinations were performed on patients before and during treatment. ten patients of 46 above-mentioned cases were excluded from treatment prot...

This study examined the effects of low doses of intravenous clonidine on regional and global sympathetic nervous system activity in heart failure. In heart failure, adrenoceptor-blocking treatments have a limited sphere of activity. Centrally acting sympatholytic therapies should be further investigated, with a specific emphasis on targeting cardiac and renal sympathetic overactivity. In 10 pat...

Use of low dose naltrexone has been advocated for a variety of medical problems. Only a few articles published in peer review journals have documented side effects of low dose naltrexone. The purpose of this study was to determine the frequency of adverse effects of low dose naltrexone in patients who have been treated for a variety of gastrointestinal disorders. The secondary purpose was to de...

OBJECTIVE To determine the frequency of adverse effects attributed to Methotrexate (MTX) toxicity and serum minimum toxic concentration with low dose MTX in Rheumatoid Arthritis (RA) patients. STUDY DESIGN Cross-sectional observational study. PLACE AND DURATION OF STUDY Department of Chemical Pathology and Endocrinology, Armed Forces Institute of Pathology, Rawalpindi, from March 2010 to Ma...

The effect of a rapid increase in circulating melatonin on body temperatures and sleepiness was investigated in eight young adults at 1000. Melatonin administered intravenously at 10- and 30-μg doses, but not 3 μg, resulted in elevated plasma and saliva levels consistent with endogenous levels measured in adults at night. Melatonin at 10 and 30 μg significantly attenuated the daytime increase i...

OBJECTIVE Low dose radiation may stimulate the growth and development of animals, increase life span, enhance fertility, and downgrade the incidence of tumor occurrence.The aim of this study was to investigate the antitumor effect and hormesis in an erythrocyte system induced by low-dose radiation. METHODS Kunming strain male mice were subcutaneously implanted with S180 sarcoma cells in the r...

Tramadol is used in treatment of moderate to severe pain. Nowadays tramadol overdose is one of the common emergencies. Naloxone is an antagonist which is used as a first step of treatment in these patients. This study was designed to evaluate the seizurogenic effects of naloxone in tramadol overdose. A number of 124 patients with the diagnosis of tramadol overdose were divided to receive low-do...

Total-body irradiation (TBI) with 0.02-0.25 Gy has been reported to have antitumor effects. In mice, low-dose TBI induces tumor growth delay, antimetastatic effects, suppressive effects on the incidence of spontaneous thymiclymphoma, sensitization of tumor to ionizing radiation, and decrease in TD50 value. In artificial metastasis, 0.20 Gy TBI suppressed lung metastasis when it was conducted be...