The problem of estimating the moduli smoothness functions from Lqin terms broader Lebesgue class Lph as been known for a long time. At initial stage, in works Titchmarsh, Hardy, Littlewood, Nikolsky, properties Lipschitz classes were studied and corresponding embeddings obtained. For continuity one variable P.L. Ulyanov proved an inequality later named after him - "Ulyanov’s inequality". classi...

An in vivo labeling technique was utilized to demonstrate the in situ biosynthesis of proopiomelanocortin (POMC)-, fl-endorphinand ol-melanotropin (MSH)-like molecular species in rat brain. Unrestrained adult female rats were bilaterally cannulated in the hypothalamic arcuate nuclear region; [““Slmethionine was infused either over a 15-min period with sacrifice 2 hr subsequently, or at a consta...

Abstract Introduction Metabolic syndrome (Met Sy) as a highly debatable cluster of traditional risk factors is known to promote cardiometabolic-related morbidity and mortality, but its precise mechanisms remain be determined. Purpose We sought determine influence MetSy on heart failure (HF) mortality in the Seven Countries' Study one oldest epidemiological studies. Methods The Countries encompa...

OBJECTIVE Silent corticotroph adenomas (SCAs) are rare pituitary tumours immunoreactive for ACTH, but without clinical evidence of Cushing's disease. We characterized SCAs based on clinical, hormonal and molecular data, and compared the characteristics of these tumours with those of macro (MCA)- and micro (mCA)-ACTH adenomas with Cushing's disease. METHODS Fifty ACTH adenomas (14 SCAs, 15 MCA...

Inhalation of high concentration of oxygen produces oxidative stress in men and experimental animals. Our previous experiments showed that the cough reflex is suppressed in guinea pigs after exposure to 100% O(2) for 60 hours. The aim of this study was to determine the effects of dietary antioxidant supplementation with vitamins C and E on hyperoxia-induced oxidative stress in airway and lung t...

Antibacterial agents which specifically inhibit CTP:CMP-3-deoxy-D-manno-octulosonate cytidylyltransferase activity were used to block the incorporation of 3-deoxy-D-manno-octulosonate (KDO) into lipopolysaccharide. Lipopolysaccharide synthesis ceased, molecules similar in structure to lipid A accumulated, and bacterial growth ceased following addition of such agents to cultures of Salmonella ty...

Background and objective: Lactose is a disaccharide sugar and is found in mammals milk and derivatives. Lactose intolerance is the inability to metabolize lactose, because of a lack of the required enzyme lactase in the digestive system. Genetically the physiological hypolactasia (primary LM) is associated with the LCT-13910 C/T and LCT-22018 G/A polymorphisms. The aim of this study focused on ...

The post-translational processing of pro-opiomelanocortin (POMC) in brain remains controversial. Classically, there was thought to be a single cell group in the arcuate nucleus with long projections through limbic structures. More recently, a second cell group was discovered in the caudal medulla. This study addresses the question of POMC processing in this region. Steady-state analysis of acid...