نتایج جستجو برای: lu 177
تعداد نتایج: 19172 فیلتر نتایج به سال:
Structure of a putative BenF-like porin from Pseudomonas fluorescens Pf-5 at 2.6 Å resolution Parthasarathy Sampathkumar,* Frances Lu, Xun Zhao, Zhenzhen Li, Jeremiah Gilmore, Kevin Bain, Marc E. Rutter, Tarun Gheyi, Kenneth D. Schwinn, Jeffrey B. Bonanno, Ursula Pieper, J. Eduardo Fajardo, Andras Fiser, Steven C. Almo, Subramanyam Swaminathan, Mark R. Chance, David Baker, Shane Atwell, Devon A...
introduction: bone pain palliation therapy is a mandate in handling end-stage cancer patients. the development of new ligands with higher stability, better pharmacokinetics and lower unwanted tissue uptakes (liver and gi) is still ongoing. methods: in this work lu-177 labeled (3-amino-1-hydroxypropane-1,1-di-yl)-bis-(phosphonate) (177lu-pamidronate; 177lu-pam ), and (3-amino-1-hydroxybutane-1,1...
A new BIPHEP-type ligand with phenyl groups at the 3,30-positions, o-Ph-MeO-BIPHEP 3 was prepared. This ligand afforded excellent enantioselectivities when used in the Rh-catalyzed asymmetric hydrogenation of a-dehydroamino acid derivatives. The strong influence of o-phenyl groups of the ligand on the enantioselectivities of the reaction has been demonstrated by a comparison with its parent lig...
The first T(d)-symmetric lutetium metallofullerene, Lu(2)@C(76), has been synthesized, isolated, and characterized. Because of the charge transfer from the encapsulated Lu atoms to the T(d)-C(76) fullerene cage, the otherwise unstable T(d)-C(76) fullerene can be significantly stabilized as a Lu(2)@C(76) fullerene. Both STM and STS results are consistent with a charge state of (Lu(2))(6+)@C(76)(...
Let f(z) = ∑∞ n=1 λf (n)e 2πinz ∈ S k (Γ0(N)) be a newform of even weight k ≥ 2 on Γ0(N) without complex multiplication. Let P denote the set of all primes. We prove that the sequence {λf (p)}p∈P does not satisfy Benford’s Law in any base b ≥ 2. However, given a base b ≥ 2 and a string of digits S in base b, the set Aλf (b, S) := {p prime : the first digits of λf (p) in base b are given by S} h...
The 2016 Great Wall International Translational Andrology and Urology Forum, and Huaxia Medical ForumGenitourinary Tumor (HMF-GUT2016 & GITAU2016) will be held at Tianjin Convention Center, Tianjin, China, April 15–17, 2016. Please visit the meeting website (http:// www.gua-hmf2016.com) for more information. HMF-GUT2016 & GITAU2016 is organized by China International Exchange and Promotive Asso...
An antibody-targeted radiation therapy (radioimmunotherapy, RIT) employs a bifunctional ligand that can effectively hold a cytotoxic metal with clinically acceptable complexation kinetics and stability while being attached to a tumor-specific antibody. Clinical exploration of the therapeutic potential of RIT has been challenged by the absence of adequate ligand, a critical component for enhanci...
BACKGROUND Advances in gamma camera technology and the emergence of a number of new theranostic radiopharmaceutical pairings have re-awakened interest in in vivo quantification with single-photon-emitting radionuclides. We have implemented and validated methodology to provide quantitative imaging of (177)Lu for 2D whole-body planar studies and for 3D tomographic imaging with single-photon emiss...
UNLABELLED Prostate-specific membrane antigen (PSMA) is an excellent target for radionuclide therapy of metastasized castration-resistant prostate cancer (mCRPC). Besides high affinity and long tumor retention, the DOTA-conjugated ligand PSMA-617 has low kidney uptake, making it an excellent choice for therapeutic application. We retrospectively report our experience with (177)Lu-PSMA-617-targe...
Prostate-specific membrane antigen (PSMA) is a well-established target for nuclear imaging and therapy of prostate cancer (PCa). Radiolabeled small-molecule PSMA inhibitors are excellent candidates for PCa theranostics-they rapidly and efficiently localize in tumor lesions. However, high tracer uptake in kidneys and salivary glands are major concerns for therapeutic applications. Here, we prese...
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