BACKGROUND The relationship between extracranial venous system abnormalities and central nervous system disorders has been recently theorized. In this paper we delve into this hypothesis by modeling the venous drainage in brain and spinal column areas and simulating the intracranial flow changes due to extracranial morphological stenoses. METHODS A lumped parameter model of the cerebro-spinal...

The vibration environment is a common man-made artificial surrounding with which humans have a limited tolerance to cope due to their body dynamics. This research studied the dynamic characteristics of a seated human body/seat system in a vibration environment. The main result is a multi degrees of freedom lumped parameter model that synthesizes two basic dynamics: (i) global human dynamics, th...

This paper presents the responses of the railway vehicle and track components in terms of contact forces and displacements. The considered vehicle model is a five-DOF pitch-plane lumped parameter quarter car model supported on two-dimensional track systems comprising three layers. The car body is linked with the vehicle bogie through secondary suspension springs and damper elements, which is fu...

BACKGROUND The OxyMask(™) is a unique, open-style, oxygen mask that was originally developed in 2005. The original mask was modified, using computational fluid dynamics numerical simulations, with the goal of allowing it to produce a wider range of FiO(2). This analysis was used to guide the modification of the mask shell and the location for the oxygen diffuser. METHODS The new OxyMask was a...

Accurate calculation of the electromagnetic force distribution transformer windings under different loads and fault conditions is great significance for maintenance, condition evaluation life prediction. Due to influence offshore wind power systems, transformers have high harmonic content large changes in load rates, which can easily cause coil destabilization, winding deformation or even damag...

Dysregulation of TNF-α in lamina propria macrophages (LPM) is a feature of inflammatory bowel diseases (IBD). LPS-Induced-TNF-Alpha-Factor (LITAF) is a transcription factor that mediates TNF-α expression. To determine whether LITAF participates in the mediation of TNF-α expression in acutely inflamed colonic tissues, we first established the TNBS-induced colonic inflammation model in C57BL/6 mi...

Modal analysis is extensively used to study dynamic behavior of continuous and lumped parameter linear systems. More specifically, modal analysis can be used for the analysis and controller design of dynamic systems. In both cases, reduction of model size without degrading the accuracy is often required for the efficient use of the model. The reduction of modal models has been extensively studi...