introduction: colorectal carcinoma is a main health problem in many countries and the third common cancer in iran. this malignancy at present is the most curable carcinoma of gastrointestinal tract. variation in the expression of the proteins produced by p53, p21, p16, e-cadherin, and β-catenin genes have been noted in this malignancy and may be important in the prognosis and therapeutic respon...

Atezolizumab plus carboplatin-etoposide (ACE) represents the new first-line (1L) standard of care for extended stage (ES) Small Cell Lung Cancer (SCLC) patients (pts). This is a single-center retrospective-prospective translational study aiming at investigating correlation immune cell distribution and their spatial metrics in tumor samples ES SCLC pts receiving ACE as 1L treatment, with respons...

Lymph nodes (LNs) are organized anatomical structures distributed at strategic sites alongside the lymphatic vasculature that provide the hub of the acquired immune system. Their organization is supported by stromal cell populations, allowing maximal interaction between antigen-loaded dendritic cells (DCs) migrating through the afferent lymphatic vasculature and recirculating lymphocytes enteri...

The presence of tumor cells in lymph nodes (LNs) is a sign that metastatic spread of cancer has occurred, and it also signals poor prognosis for patients with cancer. However, it is uncertain whether the lymphatic vasculature is a route for the further dissemination of tumor cells to distant organs or whether that primarily occurs through direct entry of tumor cells into blood vessels. Until re...

BACKGROUND Inflammatory breast cancer (IBC) remains the most aggressive type of breast cancer with the greatest potential for metastasis and as a result, the highest mortality rate. IBC cells invade and metastasize through dermal lymphatic vessels; however, it is unknown how lymphatic drainage patterns change during IBC growth and metastasis. Herein, we non-invasively and longitudinally imaged ...

Active lymph transport relies on smooth muscle cell (SMC) contractions around collecting lymphatic vessels, yet regulation of lymphatic vessel wall assembly and lymphatic pumping are poorly understood. Here, we identify Reelin, an extracellular matrix glycoprotein previously implicated in central nervous system development, as an important regulator of lymphatic vascular development. Reelin-def...

PURPOSE Nodal metastasis is the main prognostic factor in the patients with oral squamous cell carcinoma (OSCC). We investigated the association between tumor-associated lymphatics and OSCC characteristics. METHODS Thirty-four specimens were used for the immunohistochemical staining with the antibody for vascular endothelial growth factor (VEGF)-C, VEGF-D, VEGF receptor (VEGFR)-3, phosphoryla...

Highly metastatic and chemotherapy-resistant properties of malignant melanomas stand as challenging barriers to successful treatment; yet, themechanisms responsible for their aggressive characteristics are not fully defined. We show that a distinct population expressing CD133 (Prominin-1), which is highly enriched after administration of a chemotherapeutic drug, dacarbazine, has enhanced metast...

Neogenesis of lymphatic vessel and lymphatic invasion is frequently found in the stroma of cancers, but the mechanisms of this phenomenon remain unclear. Vascular endothelial growth factor C (VEGF-C) is known to be the only growth factor for the lymphatic vascular system, and its receptor has been identified as Flt4. To clarify the mechanism of lymphatic invasion in cancer, we studied the expre...