The cell-mediated immune response is critical in the resistance to and recovery from leishmaniasis. Cytokines are central elements in mounting an immune response and have received a great deal of attention in both human and experimental leishmaniasis. IFN-γ is responsible for macrophage activation leading to leishmanicidal mechanisms. Understanding the balance of cytokines that lead to enhanced...

The influence of 6% carbohydrate ingestion and age on PHA-induced lymphocyte proliferation and in vitro cytokine production was studied in 48 runners following a competitive marathon. Runners were randomly assigned to carbohydrate (C; n = 23) and placebo (P; n= 25) groups, with blood samples taken before, immediately after, and 1.5 hr post-race. C versus P ingestion resulted in higher plasma gl...

cortical spreading depression (csd) are associated with dramatic failure of brain ion homeostasis, efflux of excitatory amino acids from nerve cells, increased energy metabolism and changes in cerebral blood flow. there is strong clinical and experimental evidence to suggest that csd is involved in the mechanism of migraine, stroke, subarachnoid hemorrhage and traumatic brain injury. therefore,...

ILA, a gene induced by lymphocyte activation, is a member of the human nerve growth factor tumor necrosis factor receptor family and the human homologue of murine 4-1BB. The present study analyzed the role of ILA in the regulation of human peripheral blood T-lymphocyte function. Antibodies raised against different fusion proteins recognized ILA on activated lymphocytes. These antibodies signifi...

conclusions artemisia absinthium l. extract, at concentrations below 100 µg/ml, can modulate the immune response toward a th1 pattern, by induction of cd40 expression on dcs and cytokine production. also, it can inhibit dcs t cell stimulating activity, at high concentrations. therefore, the traditional use of this plant possibly modulates immune-mediated disorders. however, future studies are n...