Background/Aim. Thermodynamical and cryobiological parameters responsible for cell damages during cryopreservation (cryoinjuries) have not yet been completely explained. Thus, freezing procedures should be revised, exactly optimized to obtain an enhanced structural and functional recovery of frozen–thawed cells. The aim of this study was to compare microprocessor–controlled (controlled–rate) wi...

Genogroup II ehrlichia, including the agent of human granulocytic ehrlichiosis, Ehrlichia phagocytophila, and the bovine pathogen Anaplasma marginale, express a markedly immunodominant outer membrane protein designated major surface protein 2 (MSP2). MSP2 is encoded by a multigene family, resulting in the expression of variant B cell epitopes. MSP2 variants are sequentially expressed in the rep...

BACKGROUND Gene expression profiling has successfully identified the prognostic significance of the host response in lymphomas. The aggressive T-cell/histiocyte-rich large B-cell lymphoma and the indolent nodular lymphocyte-predominant Hodgkin's lymphoma are both characterized by a paucity of tumor cells embedded in an overwhelming background. The tumor cells of both lymphomas share several cha...

The mixed lymphocyte reaction is characterized by proliferation and generation of specifically cytotoxic effector lymphocytes. These two phases of the mixed lymphocyte reaction have been shown to be mediated by distinct subpopulations of thymus-derived cells. The current investigation demonstrates that combinations of cells from thymus and lymph nodes of CBA mice exhibit synergism with respect ...

Effector cells in delayed hypersensitivity and in vitro cytotoxicity were studied in lymph node cells from animals immunized with sheep erythrocytes (SRBC) in complete Freund's adjuvant. Delayed hypersensitivity response (DHR) was assayed by the increase in foot pad swelling after the intrafoot pad injection of immune cells plus antigen. Cell-mediated cytotoxicity against SRBC was assayed by a ...

A number of recent studies have suggested that the main functional role of the product of the immune response (Ir) genes is in the process of antigen recognition by the T lymphocyte. The observation in the accompanying report that the interaction of macrophage-associated antigen with immune T lymphocytes requires that both cells share histocompatibility antigens raised the question as to whethe...

BACKGROUND Although B cell depletion with rituximab (RTX) is an effective treatment strategy in rheumatoid arthritis (RA), one third of patients do not achieve remission or low disease activity (LDA). Thus, identifying patients who will benefit from RTX is highly desirable. In the present study we investigated whether lymphocyte subsets other than B cells are predictors of a clinical response t...

Noise has long been realized as an environmental stress causing physiological, psychological and behavioral changes in humans. The aim of the present study was to determine the effect of acute or chronic noise stress on both cellular and humoral immune responses and oxidative status. BALB/c mice were exposed to 90 dB (A) white noise 5 h per day for either 3 d or 4 wk. Hormone levels, splenic ly...

background : now a days researchers have shown grean interest in electromagnetic waves which spread from devices such az microwaves,satellites,tv,cell phones etc,due to various reports of their devasting effects on animal growth and health.in this study the effects of these radiations on blood cells is investigated . methods : in the present study the effect of radiation on blood parameters in ...

background coronary heart disease (chd) is the leading cause of death worldwide. research indicates that coronary atherosclerosis is the most frequent cause of chd. evidence is scarce concerning the clinical efficacy of fibrinogen or neutrophil-lymphocyte ratio (nlr) measurement in risk-stratifying patients with chronic stable angina. conclusions nlr and fibrinogen predicted cad, independent of...