objective: in the present work, the effects of different fractions of coriandrum sativum (c. sativum), on pentylenetetrazole (ptz)-induced seizures and brain tissues oxidative damage were investigated in rats. materials and methods: the rats were divided into the following groups: (1) vehicle, (2) ptz (90 mg/kg), (3) water fraction (wf) of c. sativum (25 and 100 mg/kg), (4) n-butanol fraction (...

objective: echium amoenum fisch. & c.a. mey. is used for the treatment of various diseases in traditional medicine. this plant is a major source of anthocyanins with beneficial cardiovascular properties such as anti-atherosclerotic and antihypertensive effects. in the present study, the protective and antioxidant effects of anthocyanin-rich e. amoenum extract were evaluated on human vascular en...

the aim of this study was to investigate the effects of administering antioxidants, including vitamin c and chitosan on oxidative stress markers in muscle as edible tissues of cyprinus carpio exposed to cadmium chloride. in this experiment, by exposing to 0.2 mg/l cadmium chloride for 21 days, fish were fed a normal diet, diet containing chitosan (1000 mg/kg diet), vitamin c (1000 mg/kg diet) o...

background: an increased oxidative stress in patients under treatment with high concentrations of oxygen (hyperoxia) is considered to be one of the major mechanisms of lung injury. between different mediators, transition metal ions especially iron, by generation of very reactive free radicals play an important role in oxidative stress process. disruption of normal iron hemostasis has been repor...

background: the blocking of nitric oxide synthase (nos) activity may reason vasoconstriction with formation of reactive oxygen species. propolis has biological and pharmacological properties, such as antioxidant. the aim of this study was to examine the antioxidant effects of propolis which natural product on biochemical parameters in brain and lung tissues of acute nitric oxide synthase inhibi...

background: the aim of this study was to investigate the role of oxidative stress in the pathology of ovine dicrocoeliasis. methods : during dec 2013 - oct 2014, seventy-two sheep (1-3 years) with liver dicrocoeliasis along with 47 healthy sheep were selected from animals admitted for slaughtering at slaughterhouse located in neyshabour, razavi khorasan province, iran. results : in comparison t...

background: it is well known that the development of brain oxidative stress is one of the most serious complications of arterial hypertension that evokes brain tissue damage. the aim of this study was to examine the effects of atorvastatin treatment (20 mg/kg/day), as an antioxidant, to prevent the brain tissue oxidative stress in the hypertensive (htn) rats. methods: experiments were performed...

background: diabetes mellitus in some clinical cases is accompanied with hyperalgesia. in this study, we evaluated the possible beneficial effect of chronic pelargonidin (pg) treatment on hyperalgesia in streptozotocin (stz)-diabetic neuropathic rat. methods: male wistar rats (n = 56) were divided into seven groups, i.e. control, diabetic, pg-treated control, pg (single- and multiple-dose)-trea...

background: gallic acid (ga) is an endogenous plant phenol known to have antioxidant, free radical scavenging ability, anti‑inflammatory, anti‑cancer, and anti‑fungal properties. the aim of this study was to assess the protective effect of ga on cyclophosphamide (cpa)‑induced hepatotoxicity in male wistar rats. methods: sixty rats were grouped into six groups of 10 rats per group. group 1 recei...

cardiac disorders remain one of the most important causes of death in the world. oxidative stress has been suggested as one of the molecular mechanisms involved in drug-induced cardiac toxicity. recently, several natural products have been utilized in different studies with the aim to protect the progression of oxidative stress-induced cardiac disorders. there is a large body of evidence that a...