Cadherins are a family of cell-cell adhesion molecules and are divided into subclasses with distinct adhesive specificities and tissue distribution. Here we examined the distribution of cadherins at contact sites between cells expressing the same or different cadherin subclasses. Each cadherin was concentrated at the boundary between cells expressing an identical cadherin subclass, irrespective...

1 Dodick DW, Goadsby PJ, Spierings ELH, Scherer JC, Sweeney SP, Grayzel DS. Safety and effi cacy of LY2951742, a monoclonal antibody to calcitonin gene-related peptide, for the prevention of migraine: a phase 2, randomised, double-blind, placebo-controlled study Lancet Neurol 2014; published online Aug 11. http://dx.doi.org/10.1016/S1474-4422(14)70128-0. 2 Goadsby PJ, Edvinsson L, Ekman R. Rele...

Exposure of bovine aortic or capillary endothelial cells to basic FGF (bFGF) for 1 h resulted in an approximately sixfold increase in plasminogen activator (PA) activity by 18 h that returned nearly to basal levels by 36 h. We hypothesized that the decrease in PA activity following bFGF stimulation was mediated by transforming growth factor/3 (TGF-/3) formed from its inactive precursor. Conditi...

Timing of surface uplift of the Tibetan Plateau has received much attention because of proposed links between high topography and change in regional and global climate, southern Asian paleoecology, and ocean chemistry (Quade et al., 1989; Edmond, 1992; Prell and Kutzbach, 1992; Raymo and Ruddiman, 1992; Molnar et al., 1993; Derry and France-Lanord, 1996). However, the actual vintage of high ele...

1 Ruder MA, Davis JC, Eldar M, Abbott JA, Griffin JC, Seger Jj, MM. Clinical and electrophysiologic characterization of automatic junctional tachycardia in adults, Circulation 1986; 73:930-37 2 Santinelli V, Chiariello M, Condorelli M. Junctional ectopic tachycardia and verapamil. Chest 1984; 85:121-22 3 Santinelli V. De Paola M, Smimmo D, Chiariello M, Condorelli M. Further observations on jun...

In teleosts, a startle response occurs when one of a pair of Mauthner cells (Mcells) originating in the fish hindbrain is excited by sensory afferents and fires a single action potential. This action potential propagates caudally along the M-axon, which crosses the midline and continues tailward within the spinal cord. In passage, the M-spike excites (via collaterals) primary motor neurons with...

Robust alternatives to the seemingly unrelated regression (SUR) estimator of Zellner (1962) are proposed for the classical multivariate regression model. These weighted M-estimators achieve an asymptotic covariance matrix analogous to that of the SUR estimator. Comparisons are made with the efficient estimator in the case of elliptically contoured distributions. The / lt least absolute deviatio...

1 Campbell M. Natural history of coarctation of the aorta. Br Heart J 1970; 32:633–640 2 Perloff JK. Coarcation of the aorta. In: The clinical recognition of congenital heart disease. Philadelphia, PA: W.B. Saunders, 1999; 132–169 3 Behl PR, Sante P, Blesovsky A. Isolated coarctation of the aorta: surgical treatment and late results: eighteen years’ experience. J Cardiovasc Surg 1988; 29:509–51...

This article provides a comparison of typical properties the principal features mainand auxiliary verbs and study tense categories moods historical Mamluk-Kipchaklanguage in with modern Kazakh language considering such well-known writtensources Mamluk-Kipchak XIIІ-XV centuries as “Kitab al-Idrak Li-Lisan Al-Atrak”, majmua tirjuman turki ua ajami muguli farsi”, ad-durra al-mudiyya fial-luga”, At...

This paper specializes the signature forgery by Coron, Naccache and Stern (1999) to Rabin-type systems. We present a variation in which the adversary may derive the private keys and thereby forge the signature on any chosen message. Further, we demonstrate that, contrary to the RSA, the use of larger (even) public exponents does not reduce the complexity of the forgery. Finally, we show that ou...