نتایج جستجو برای: m peg pcl

تعداد نتایج: 557696  

2012
Fansheng Kong Fang Zhou Linfu Ge Ximin Liu Yong Wang

BACKGROUND Liposomes can be modified with different ligands to control their biological properties, such as longevity, targeting ability, and intracellular penetration, in a desired fashion. The aim of this study was to modify liposomes with a novel mannosylated polyethylene glycol-phosphatidylethanolamine (M-PEG-PE) ligand to achieve active targeted gene delivery. METHODS Rat Kupffer cells w...

2014
Eduardo Luzía França Elton Brito Ribeiro Edson Fredulin Scherer Déborah Giovanna Cantarini Rafael Souza Pessôa Fernando Luzía França Adenilda Cristina Honorio-França

An evaluation of the rheological properties and the effects of Momordica. charantia L. (M. charantia) nanoparticles and polyethylene glycol (PEG) microspheres adsorbed with M. charantia nanoparticles on the blood of hyperglycemic patients is presented. Blood samples were collected according to glycemic status: normoglycemic (N = 56) and hyperglycemic (N = 26). General and hematological characte...

2018
Shan Xu Xiaobo Du Gang Feng Yu Zhang Jie Li Binwei Lin Linglin Yang Shaozhi Fu Jingbo Wu

Background and Purpose We aimed to explore the anti-tumor effect and mechanism of the combination of cisplatin (DDP)-containing thermosensitive hydrogel (PEG-PCL-PEG, or PECE) and paclitaxel (PTX)-loaded MPEG-PCL polymeric micelles called PDMP on human cervical carcinoma (HeLa) cell. In our previous studies, we found that PDMP in situ treatment of lung cancer will be liable to have potential in...

Journal: :The Biochemical journal 2009
Martijn J Koetsier Peter A Jekel Marco A van den Berg Roel A L Bovenberg Dick B Janssen

Enzymatic activation of PAA (phenylacetic acid) to phenylacetyl-CoA is an important step in the biosynthesis of the beta-lactam antibiotic penicillin G by the fungus Penicillium chrysogenum. CoA esters of PAA and POA (phenoxyacetic acid) act as acyl donors in the exchange of the aminoadipyl side chain of isopenicillin N to produce penicillin G or penicillin V. The phl gene, encoding a PCL (phen...

Journal: :Acta biomaterialia 2018
Alexander R Brunelle Christopher B Horner Karen Low Gerardo Ico Jin Nam

Hydrogels have shown great potential for cartilage tissue engineering applications due to their capability to encapsulate cells within biomimetic, 3-dimensional (3D) microenvironments. However, the multi-step fabrication process that is necessary to produce cell/scaffold constructs with defined dimensions, limits their off-the-shelf translational usage. In this study, we have developed a hybrid...

Journal: :Biomacromolecules 2015
Sebastian Wieczorek Timm Schwaar Mathias O Senge Hans G Börner

Combining poly(ethylene glycol) (PEG) with sequence-defined peptides in PEG-peptide conjugates offers opportunities to realize next-generation drug formulation additives for overcoming undesired pharmacological profiles of difficult small molecule drugs. The tailored peptide segments provide sequence-specific, noncovalent drug binding, and the hydrophilic PEG block renders the complexes water s...

2009
Luis Manuel Orozco-Castellanos Angel Marcos-Fernández Antonio Martínez

Asymmetric telechelic α-hydroxyl-ω-(carboxylic acid)-poly(ε-caprolactone) (HA-PCL), α-hydroxyl-ω-(benzylic ester)-poly(ε-caprolactone) (HBz-PCL) and an asymmetric telechelic copolymer α-hydroxyl-ω-(carboxylic acid)-poly(ε-caprolactone-co-γbutyrolactone) (HA-PCB) were synthesized by ring-opening polymerization of εcaprolactone (CL). CL and CL/γ-butyrolactone mixture were used to obtain homopolym...

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