the core spliceosome? How is RBM15’s association with specific genes regulated? What is the dominant-negative mechanism by which Mpl-TR acts to decrease HSC maintenance? Answers to these questions not only will elucidate critical aspects of the splicing machinery, but will be relevant for our understanding of the role of the RBM15-MKL1 fusion protein in AMKL. Conflict-of-interest disclosure: Th...

DNA replication is a fundamental biological process involving numerous enzymes that help to ensure the maintenance of genomic integrity. DNA polymerase enzymes are key components of this cellular replication machinery. Their primary function is to selectively incorporate correct nucleotide [i.e., a dNTP (where N1⁄4A, T, C or G), 20-deoxyribonucleoside 50-triphosphate] to pair with the template ...

Mechanical forces are crucial to muscle development and function, but the mechanisms by which forces are sensed and transduced remain elusive. Evidence implicates the sarcolemmal lattice of integrin adhesion and the Z-disk components of the contractile machinery in such processes. These mechanosensory devices report changes in force to other cellular compartments by self-remodeling. Here we exp...

The small GTPase Arf1 that is classically required for the budding of COPI-coated vesicles from the Golgi membrane is now proposed to have novel and conserved roles in the morphological and functional maintenance of mitochondria: It functionally localizes to ER/mitochondria contact sites; it allows for the recruitment of a degradation machinery to mitochondria to remove toxic mitofusin/Fzo1 clu...

The maintenance of mitochondrial DNA (mtDNA) is dependent upon several nuclear gene-encoded proteins including enzymes forming the replisome needed to synthesise mtDNA. These need be present in balanced quantities function properly. In addition, mtDNA synthesis requires a supply nucleotides that achieved by nucleoside recycling inside mitochondria, and nucleotide import from cytosol. Mitochondr...

Even if usually filled in the form of unstructured text, maintenance service reports can be an important source information for manufacturing companies providing field and remote services to their customers. By analyzing content, discover hidden knowledge that used improvement purposes. exploiting Natural Language Processing (NLP) techniques, this paper wants show how Italian company producing ...

The Jakarta-Bandung high-speed rail infrastructure project delays cause the financial burden in form of interest during construction to swell KCIC had improve performance by carrying out at night and must strategies for dealing with Indonesian extreme weather. Before night, strict inspection shall also be focused on lighting lamps. Construction personnel prepare flashlights, searchlights, all p...

Genomic instability is both a hallmark of cancer and a major contributing factor to tumor development. Central to the maintenance of genome stability is the repair of DNA damage, and the most toxic form of DNA damage is the DNA double-strand break. As a consequence the eukaryotic cell harbors an impressive array of protein machinery to detect and repair DNA breaks through the initiation of a mu...

Fault diagnosis is important for the maintenance of rotating machinery. The detection of faults and fault patterns is a challenging part of machinery fault diagnosis. To tackle this problem, a model for deep statistical feature learning from vibration measurements of rotating machinery is presented in this paper. Vibration sensor signals collected from rotating mechanical systems are represente...

Abstract Vibration measurement and monitoring are essential in a wide variety of applications. measurements critical for diagnosing industrial machinery malfunctions because they provide information about the condition rotating equipment. analysis is considered most effective method predictive maintenance it used to troubleshoot instantaneous faults as well periodic maintenance. Numerous studie...