The nature of the increased vascular resistance in chronic hypertension has been the subject of much investigation and speculation. The evidence strongly suggests that this resistance is mainly at arteriolar level; hence the arterioles are often referred to as the resistance vessels. When hypertension was first recognized, it was thought that structural changes in the arterioles and capillaries...

During early embryonic development, certain groups of cells, like neural crest cells, can transiently express locomotory properties that allow them to migrate long distances from their sites of origin and populate other areas of the embryo where they undergo differentiation (Le Douarin, 1982; Newgreen and Erickson, 1986; Levi et al., 1990; Erickson and Perris, 1993). During migration to their f...

The structure of polyacrylamide gels was studied using proton spin-lattice relaxation and PFG diffusion methods. Polyacrylamide gels, with total polymer concentrations ranging from 0.25 to 0.35 g/ml and crosslinker concentrations from 0 to 10% by weight, were studied. The data showed no effect of the crosslinker concentration on the diffusion of water molecules. The Ogston-Morris and Mackie-Mea...

As President of the International Society for Laboratory Hematology (ISLH), now is time to report on major activities and accomplishments ISLH. This past year has been like no other with challenges around world due ongoing COVID-19 pandemic. Despite this, our members society have met this adversity, including transitioning ISLH's annual conference successful first virtual in 2020 (over 2338 att...

It has been suggested that substrate adhesion molecules of the tenascin family may be responsible for the segmented outgrowth of motor axons and neural crest cells during formation of the peripheral nervous system. We have used two monoclonal antibodies (M1B4 and 578) and an antiserum [KAF9(1)] to study the expression of J1/tenascin-related molecules within the somites of the chick embryo. Neur...

There is a general philosophical problem with the status of non-objective judgements, such as evaluative or aesthetic judgements. On the one hand, even judgements in these areas seem to answer to some standard of correctness. They are not arbitrary. We often call them " true " or " false ". One can err in making them. We argue about them. On the other hand, there are reasons to say these judgem...

An integrated stratigraphic, paleoecological, and geochronological study of lake and fen sediments just beyond the terminus of Berendon Glacier provides insights into late Holocene climate, vegetation, and glacier change in the northern Coast Mountains of British Columbia. Cores collected from two small lakes in the foreland of Berendon Glacier and pits dug in a nearby fen record Little Ice Age...

This report describes a case of a 72-year-old Caucasian woman presenting with a large neurotrophic keratitis with a large persistent epithelial defect, with a longest linear diameter of 7 mm and greatest perpendicular width of 5 mm, affecting epithelium, Bowman membrane, and anterior stroma. Corneal disease was resistant to conventional treatment and classified as stage 2 according to Mackie cl...

mens were homogenized using a modified Petroff's method. Sputum was treated as described by Mackie and McCartney (1953) except that after removing the supernatant fluid subsequent to centrifuging for half an hour at 3,000 r.p.m. the neutralized deposit was centrifuged further for 5 min. at 1,000 r.p.m. This second spinning deposited the coarser particles of debris inseparable from sputum concen...

Abstract Background/Aims Recognition of jaw claudication is crucial to expedite diagnosis and treatment giant cell arteritis (GCA). The ACR 1990 criteria defined the jaw, tongue or deglutition as “development worsening fatigue discomfort in muscles mastication, tongue, swallowing while eating”. We sought describe diverse ways which patients may this key GCA symptom its impact on health-related ...