When I started writing the paper [19] in 2003 a Google search of the word “copula” gave 10,000 responses. In September 2005 the same search gives 650,000 responses. There is an explosion of activity. What is going on? Many of the web-sites found in the Google search are related to mathematical finance, statistics, extreme value theory, and risk management. Everybody who opens any journal on sto...

Imagine trying to count grains of rice in a cup that are shaking about, and then assume the grains are less than a nanometer long. This is akin to what David Hume and colleagues from the University of Heidelberg in Germany have recently done [1]. As reported in Physical Review Letters, by observing the light emitted from a collection of laser-cooled and trapped atoms, they can distinguish two e...

the unfinished or very short cook's tale is an exception among the canterbury tales. this quality didn't make the author or later editors to dismiss it from the collection. yet, it made the tale absent from almost all anthologies and caused it to suffer from the negligence of most critics and chaucer scholars. however, both the narrator of the tale, who is a lower class londoner livin...

Naturally TALEs are pathogenicity factors secreted by Xanthomonas spp. into host plant cells to bind specific promoters and manipulate host transcription. Sequence specific DNA binding is conferred by the TALE repeat array. Natural TALE repeat arrays are formed of 10-30 repeats, each of which pairs with one DNA base. Collectively the repeats of a TALE array form a righthanded superhelix, enfold...

Engineered transcription activator-like effectors, or TALEs, have emerged as a new class of designer DNA-binding proteins. Their DNA recognition sites can be specified with great flexibility. When fused to appropriate transcriptional regulatory domains, they can serve as designer transcription factors, modulating the activity of targeted promoters. We created tet operator (tetO)-specific TALEs ...

This article debates the merits of fairy tale interpretive frameworks that privilege the psychological and symbolic, versus those that utilize a literal and feminist orientation. Using ATU 510B as a test case, for its intriguing blend of real-world elements and the fantastic, the author suggests that a synthesis of literal and symbolic theories allows for the fullest understanding of the polyva...

La conversión de un esquema de bases de datos en otro con mayor contenido semántico es un tema de investigación actual, y un tópico con aplicación en varias áreas de desarrollo tales como integración de esquemas, migración de sistemas “legacy” y reingeniería de modelos de datos desactualizados o de pobre calidad. Las dependencias de inclusión constituyen uno de los conceptos clave para llevar a...

Aphasia can globally or selectively affect comprehension and production of verbal and written language. Discourse analysis can aid language assessment and diagnosis. Objective [1] To explore narratives that produce a number of valid indicators for diagnosing aphasia in speakers of Brazilian Portuguese.[2] To analyze the macrostructural aspects of the discourse of normal individuals.[3] To ana...

Live imaging of the dynamics of nuclear organization provides the opportunity to uncover the mechanisms responsible for four-dimensional genome architecture. Here, we describe the use of fluorescent protein (FP) fusions of transcription activator-like effectors (TALEs) to visualize endogenous genomic sequences in Arabidopsis thaliana. The ability to engineer sequence-specific TALEs permits the ...