BACKGROUND Recent observations associate plaque instability with expansive arterial remodeling, suggesting a common driving mechanism. METHODS AND RESULTS To demonstrate that macrophages, a characteristic of vulnerable plaques, also assist in expansive remodeling, we compared carotid artery remodeling due to formation of experimental macrophage-rich and macrophage-poor lesions in the flow ces...

The interactions were analyzed between actin, myosin, and a recently discovered high molecular weight actin-binding protein (Hartwig, J. H., and Stossel, T. P. (1975) J. Biol Chem.250,5696-5705) of rabbit alveolar macrophages. Purified rabbit alveolar macrophage or rabbit skeletal muscle F-actins did not activate the Mg2+ATPase activity of purified rabbit alveolar macrophage myosin unless an ad...

Introduction. Adult-onset Still?s disease is a rare inflammatory disorder of unknown etiology. It can be complicated by macrophage activation syndrome, potentially life-threatening condition. While syndrome and adult-onset share similar features, early recognition very difficult in clinical praxis. Case outline. We report young woman, whose illness was presented suddenly, with spiking fever, so...

Abstract The distinct immune landscape of glioblastoma (GBM) from other cancer is an obstacle to GBM treatment. To overcome the limited efficacy therapy, identifying interaction between tumor and infiltrated cells needed. function B against tumors recently focused on understand microenvironments. However, there are still few studies in glioblastoma. Here, we identify cell population deficient m...

OBJECTIVE Our recent studies have highlighted membrane type-1 matrix metalloproteinase (MMP)-14 as a selective marker for an invasive subset of macrophages potentially related to atherosclerotic plaque progression. Moreover, colony stimulating factors (CSF) may exert divergent effects on macrophage MMP expression, possibly through microRNAs. We, therefore, aim to identify and test the pathophys...

background: in the present era, delinquency in children and adolescents is undoubtedly a difficult and upsetting issue attracting the attention of many experts such as psychologists, sociologists, and criminologists. these experts often try to answer why a number of children and adolescents engage in various crimes such as aggressive and anti-social crimes. they also try to find out how these c...

Hemopoietic colony-forming cells committed to macrophage differentiation (M-CFC) are selectively and differentially inhibited by prostaglandin E (PGE). A hierarchy of sensitivity was observed among murine CFC stimulated by colony-stimulating factors (CSF) which differ in their ability to initiate proliferation of morphologically distinct colony types, or stimulated by CSF provided by macrophage...

The macrophage is exquisitely sensitive to its microenvironment, as demonstrated primarily through in vitro study. Changes in macrophage phenotype and function within the atherosclerotic plaque have profound consequences for plaque biology, including rupture and arterial thrombosis leading to clinical events such as myocardial infarction. We review the evidence for dynamic changes in macrophage...

OBJECTIVE Macrophage foam cells are characterized by increased oxidative stress. Macrophage urokinase plasminogen activator (uPA) was shown to contribute to atherosclerosis progression. We hypothesized that uPA atherogenicity is related to its ability to increase macrophage oxidative stress. Increased macrophage oxidative stress in turn was shown to enhance PON2 expression. In the present study...