A hasnyálmirigy-adenocarcinoma az egyik legmagasabb halálozású daganat, medián ötéves túlélése 7-8%, korai diagnosztikája, eredményes kezelése kihívást jelent. daganatos betegségekhez, így a pancreasrákhoz is gyakran társul mikrobiom összetételének megváltozása (dysbiosis), amelyet onkobiózisnak nevezünk. Maga pancreas kolonizálódik (pl. többek között Helicobacter pylorival és Malassezia-fajokk...

While the daily papers and women's maga^'Iles print frequent and regular articles on the Puririging of children, and at the/ same time unierous excellent text-books on the subject e published, these are usually mainly con^rned with the health of the baby and small ftud. Occasionally, though much more rarely, subject of the diet and care of adolescents Cr?ps up, and it is seldom that we have pre...

Replication factor C (RF-C) is a heteropentameric protein essential for DNA replication and repair. It is a molecular matchmaker required for loading of proliferating cell nuclear antigen (PCNA) onto double-stranded DNA and, thus, for PCNA-dependent DNA elongation by DNA polymerases delta and epsilon. To elucidate the mode of RF-C binding to the PCNA clamp, modified forms of human PCNA were use...

In the O1 strain of Klebsiella, the lipopolysaccharide (LPS) O-antigen is composed of D-galactan I and D-galactan II. Although the composition of the O1 antigen of Klebsiella was resolved more than two decades, the genetic locus involved in the biosynthesis of D-galactan II and the role of D-galactan II in bacterial pathogenesis remain unclear. Here, we report the identification of the D-galact...

Klebsiella pneumoniae is an opportunistic pathogen that is responsible for causing nosocomial and community-acquired infections. Despite its common presence in soil and aquatic environments, the virulence potential of K. pneumoniae isolates of environmental origin is largely unknown. Hence, in this study, K. pneumoniae isolated from the estuarine waters and sediments of the Matang mangrove estu...

BACKGROUND Primary pyogenic liver abscess (PLA) with septic complication by Klebsiella pneumoniae is an emerging infectious disease. METHODS AND RESULTS Using DNA microarray hybridization, we identified a 20-kb chromosomal region that contained 15 open-reading frames (ORFs), including an iron-uptake system (kfu), a phosphoenolpyruvate sugar phosphotransferase system (PTS), and 6 unknown ORFs....

2021-ben Kínában megjelent egy tangping néven elhíresült mozgalom, aminek lényege, hogy arra bátorítja a kínaiakat, hagyjanak fel karrierépítéssel, ne dőljenek be az üres materialista ígéreteknek, inkább hátra és élvezzék életet. A jelenség alapvetően 20-as 30-as éveikben járó, képzett munkaerő körében terjedt el, akik nélkülözhetetlen építőkockái (lennének) tudásalapú társadalom felépítésének ...