Previous studies suggest that magnesium chloride may have discriminative stimulus effects that partially overlap with those of noncompetitive N-methyl-D-aspartate antagonists as well as certain monoamine uptake inhibitors. In our study, rats were trained to discriminate 100 mg/kg magnesium chloride from saline and its discriminative stimulus effects were characterized with respect to N-methyl-D...

Magnesium is an essential ion that has an important role in regulating cell cycles and maintaining genomic stability (1). Administration of supplemental magnesium in animals with experimentally induced colon cancer resulted in fewer colon tumors and smaller cryptal cells of the colon (2), suggesting an inhibitory role of magnesium in colon cancer cell proliferation. The mechanism by which magne...

Magnesium is an essential divalent metal that serves many cellular functions. While most divalent cations are maintained at relatively low intracellular concentrations, magnesium is maintained at a higher level (∼0.5-2.0 mM). Three families of transport proteins were previously identified for magnesium import: CorA, MgtE, and MgtA/MgtB P-type ATPases. In the current study, we find that expressi...

Magnesium is one of the most essential mineral in the human body, connected with brain biochemistry and the fluidity of neuronal membrane. A variety of neuromuscular and psychiatric symptoms, including different types of depression, was observed in magnesium deficiency. Plasma/serum magnesium levels do not seem to be the appropriate indicators of depressive disorders, since ambiguous outcomes, ...

UNLABELLED Magnesium, the second most abundant intracellular divalent cation, is a cofactor of many enzymes involved in glucose metabolism. Magnesium has an important role in insulin action, and insulin stimulates magnesium uptake in insulin-sensitive tissues. Impaired biological responses to insulin is referred to as insulin resistance. This review was designed to reach a better understanding ...

PURPOSE OF REVIEW Recent studies have greatly increased our knowledge concerning the molecular mechanisms of renal magnesium handling. This review highlights the functional features of the newly identified transient receptor potential channel melastatin subtype 6 (TRPM6), which forms the gatekeeper of active magnesium reabsorption in the kidney. RECENT FINDINGS TRPM6 confines a magnesium perm...

The magnesium concentrations in plasma and cells could be affected by diet, disease and genetic factors. To characterise the genetic factors involved in the regulation of magnesium homeostasis, Low (MgL) and High (MgH) magnesium status mice were developed by bidirectional selective breeding. The effects of a low-magnesium diet on the magnesium status parameters were analysed in these mice. Usin...

OBJECTIVES To determine the response of nebulized magnesium sulfate on the lung function of acetylcholine-induced asthma children. METHODS Three hundred and thirty children of asthma with positive bronchial provocation test were randomly divided into three groups: magnesium sulfate, albuterol, and a combination of magnesium sulfate and albuterol. Lung function was compared between the three g...

Magnesium sulphate has previously been used as a purgative in a test involving the measurement of the faecal excretion of pancreatic enzymes. In order to validate the use of magnesium sulphate for this purpose, in 18 individuals the pancreatic and biliary response to intravenous infusion of secretin (1 CU/kg-h) plus CCK(1IU/kg-h) were compared with the responses to one of three dose-rates of ma...

Background and Purpose—Magnesium sulfate is used extensively for prevention of eclamptic seizures. Empirical and clinical evidence supports the effectiveness of magnesium sulfate; however, questions remain as to its safety and mechanism. This review summarizes current evidence supporting the possible mechanisms of action and several controversies for magnesium sulfate treatment. Summary of Revi...