Targeted drug delivery has long been extensively researched since drug delivery and release at the diseased site with minimum dosage realizes the effective therapy without adverse side effects. In this work, to achieve enhanced intracellular uptake of anticancer drug carriers for efficient chemo-therapy, we have designed targeted multifunctional anticancer drug carrier hydrogels. Temperature-re...

1982). It is not clear how the rate of entry into lysosomes themselves is affected, but it may be retarded. The situation is even more obscure in the case of entry into lysosomes by autophagy. There are some indications of abnormalities in endogenous protein breakdown, and in perhaps of the lysosomal component thereof, in I-cell disease (Cockle & Dean, 1984). Similarly, Sameshima et al. (1981) ...

1 In the past few years, considerable advances of basic and application researches have taken place in the field of pharmaceutics. The newly recognized research thrust on nanoand microencapsulation is expected to have a revolutionary impact on the human health. To do this, considerable interest has been devoted towards the design of new drug delivery systems with the aim to specifically target ...

Magnetic targeting is useful for intravascular or intracavitary drug delivery, including tumor chemotherapy or intraocular antiangiogenic therapy. For all such in vivo applications, the magnetic drug carrier must be biocompatible and nontoxic. In this work, we investigated the toxic properties of magnetic nanoparticles coated with polyethylenoxide (PEO) triblock copolymers. Such coatings preven...

A carrier system based on nanoporous silica (SBA-15) with magnetic nanoparticles of CoFe2O4 was synthesized via the impregnation of cobalt salt, iron salt and citric acid with as-synthesized SBA-15. The obtained samples were characterized by small angle X-ray scattering (SAXS), N2 adsorption/desorption, scanning electron microscopy (SEM), vibrating sample magnetometer (VSM) and ultraviolet (UV)...

Abstract Magnetic spinel ferrite nanoparticles (SFNPs) attract high scientific attention from researchers due to their broad area for biomedicine applications, comprising cancer magnetic hyperthermia and targeted drug delivery. Uniquely, its excellent performance, namely, tuning size surface morphology, magnetism, extraordinary magnetically heat induction, promising biocompatibility, specific t...

In this critical review, we outline various covalent and non-covalent approaches for the functionalization of iron oxide nanoparticles (IONPs). Tuning the surface chemistry and design of magnetic nanoparticles are described in relation to their applicability in advanced medical technologies and biotechnologies including magnetic resonance imaging (MRI) contrast agents, targeted drug delivery, m...

The aim of the present study was to observe the in vivo targeting characteristic of angiopoietin 2-small interfering RNA (Ang2-siRNA) plasmid/chitosan magnetic nanoparticles in an established nude mouse model of malignant melanoma (MM) under an external magnetic field. The nude mouse MM model was first established, then divided into 3 groups, including the control group, the non-targeting group...

A carrier system based on nanoporous silica (SBA-15) with magnetic nanoparticles of CoFe2O4 was synthesized via the impregnation of cobalt salt, iron salt and citric acid with as-synthesized SBA-15. The obtained samples were characterized by small angle X-ray scattering (SAXS), N2 adsorption/desorption, scanning electron microscopy (SEM), vibrating sample magnetometer (VSM) and ultraviolet (UV)...