GABAA receptors (GABAARs) are usually formed by , , and or subunits. Recently, -containing GABAARs expressed in Xenopus oocytes were found to be sensitive to low concentrations of ethanol (1–3 mM). Our objective was to replicate and extend the study of the effect of ethanol on the function of 4 3 GABAARs. We independently conducted three studies in two systems: rat and human GABAARs expressed i...

Au Québec, la géopolitique n'a pas suscité, comme domaine de recherche, vifs débats épistémologiques en France ou ailleurs dans le monde. A croisée des écoles française et anglo-saxonne, québécoise a connu un développement progressif, avec quelques pionniers les années 1960, pour s'ancrer paysage disciplinaire géographie 1980. La sous-discipline d'abord été portée par enjeux géopolitiques liés ...

This study examined the relationships between collective self-esteem (CSE), job satisfaction (professional outcome), and subjective well-being (personal outcome) in Israeli creative arts therapies students as compared to practitioners (N=233). Based on self-enhancement theory and conservation of resources theory, the roles of work engagement and meaningful work as two parallel mediators in thes...

TREM2 is a pattern recognition receptor, expressed on microglia and myeloid cells, detecting lipids A? inducing an innate immune response. Missense mutations (e.g., R47H) of increase risk Alzheimer's disease (AD). The soluble ectodomain wild-type (sTREM2) has been shown to protect against AD in vivo, but the underlying mechanisms are unclear. We show that oligomers bind cellular TREM2, shedding...

Pecan bacterial leaf scorch (PBLS) and the pathogen Xylella fastidiosa were identified in 20 pecan cultivars observed in Louisiana commercial orchards over a twoyear period. The disease occurred in the majority of orchards observed and was distributed throughout the pecan growing areas of the state. Leaf scorch was most prevalent in the Cape Fear cultivar. A few other cultivars sometimes exhibi...

Substantial efforts have been made recently to compare the effectiveness of traditional course formats to alternative formats (most often, online delivery compared to traditional on-site delivery). This study examines, not the delivery format but rather the evaluation format. It compares traditional paper and pencil methods for course evaluation with electronic methods. Eleven instructors took ...

Polarized and unpolarized triple-axis neutron measurements were performed on an underdoped crystal of YBa2Cu3O7−x (x = 0.4 ± 0.02, Tc = 62.7 K). Our results indicate, contrary to earlier evidence, that the spin excitations in the superconducting state are essentially the same as those in the fully doped material except that the unusual 41 meV resonance is observed at 34.8 meV. The normal state ...

The effect of adrenalectomy on the expression of adenosine receptors and their mRNA in rat brain was examined using quantitative autoradiography and in situ hybridization. 1,3[H]Dipropyl-8-cyclopentylxanthine ([H]DPCPX), a selective adenosine A1 receptor antagonist, and [ H]CGS 21680, a selective adenosine A2A receptor agonist, were used as radioligands. One week after adrenalectomy, the expres...

The effect of adrenalectomy on the expression of adenosine receptors and their mRNA in rat brain was examined using quantitative autoradiography and in situ hybridization. 1,3[H]Dipropyl-8-cyclopentylxanthine ([H]DPCPX), a selective adenosine A1 receptor antagonist, and [ H]CGS 21680, a selective adenosine A2A receptor agonist, were used as radioligands. One week after adrenalectomy, the expres...

Nature takes advantage of induced proximity to perform various functions. Taking inspiration from nature, we can also trigger desired biological processes using bifunctional small molecules that artificially induce proximity. For example, have been designed the ubiquitin-dependent proteasomal degradation intracellular proteins. Now, recent classes compounds developed degrade extracellular targe...