Networks of co-regulated transcripts in genetically diverse populations have been studied extensively, but little is known about the degree to which these networks cause similar co-variation at the protein level. We quantified 354 proteins in a genetically diverse population of yeast segregants, which allowed for the first time construction of a coherent protein co-variation matrix. We identifi...

The basic components of pharmacokinetics are absorption, distribution, metabolism, and excretion. During pregnancy there may be changes in one or many of these components. Early drug studies did not include a representative proportion of women, however, researchers as well as regulators agree that studies on the sex differences in the disposition of drugs are important, but at what stage in the...

The ability to predict structure from sequence is particularly important for toxins, virulence factors, allergens, cytokines, and other proteins of public heath importance. Many such functions are represented in the parallel /-helix fold class. Structure prediction for this fold is a challenging computational problem because there exists very little sequence similarity (less than 15%) across th...

Cancer cell migration is involved in tumour metastasis. However, the relationship between calcium signalling and cancer migration is not well elucidated. In this study, we used the human lung adenocarcinoma A549 cell line to examine the role of endoplasmic reticulum protein 44 (ERP44), which has been reported to regulate calcium release inside of the endoplasmic reticulum (ER), in cell migratio...

The knowledge of the spatial conformation of a protein can help the study of its function, but the number of resolved structures is still limited by the low throughput of the methods used. Structure prediction could bridge the sequence-structure gap, but no reliable and general methods have yet been proposed. An attempt to simplify the problem has been made by trying to predict the contact map ...

The clinical data and imaging studies of 12 patients with intramedullary metastases were reviewed retrospectively to see if these lesions had a typical radiographic appearance and to determine the sensitivity of the various radiologic examinations. The lesions were identified antemortem by either myelography, CT, MR, and/or intraoperative spinal sonography (IOSS). Final diagnosis was based on b...

Introduction: This abstract is concerned with the probability that a mission to a site within the South Pole-Aitken basin (SPA) would yield a meaningful sample of typical SPA floor material. The probability seems favorable, barring a highly atypical landing site, because the chemical composition of the SPA interior, as determined remotely from orbit, is different from that of the surrounding lu...

E. B., a confectioner, aged 42, was seen by Mr. Cridland at Stafford on January 19, 1928, and was admitted under his care to the Wolverhampton. and Midland Counties Eye Infirmary for complete investigation of possible causes of the serious reduction of visual acuity and defective colour vision which had gradually developed during tlhe previous twelve months. The patient had experienced severe f...