Our objective was to determine if the insulin-sensitizing drug pioglitazone acutely reduces insulin secretion and causes metabolic deceleration in vivo independently of change in insulin sensitivity. We assessed glucose homeostasis by hyperinsulinemic-euglycemic and hyperglycemic clamp studies and energy expenditure by indirect calorimetry and biotelemetry in male Wistar and obese hyperinsuline...

objective(s) in recent years concerns have been raised regarding the incidence of male reproductive disorders from exposure to endocrine disruptors. so, chronic effects of di(2-ethylhexyl)phthalate were studied on histological and stereological structure of testis in adult wistar rats. materials and methods thirty two adult wistar rats were randomly divided in four equal experiment groups; oil ...

introduction: the aim of this work was to evaluate the effects of four different concentrations of aloe vera extract on healing of second degree burns in male wistar rats. materials and methods: by an experimental study 42 male wistar rats were divided into 7 equal groups. the burn injury was made on the back of all rats, according to standard methods. the burned areas in the group1: were left ...

Epilepsy is a neurological disorder associated with excitatory and inhibitory imbalance within the underlying neural network. This study evaluated inhibitory γ-amino-butyric acid (GABA)ergic modulation in the CA1 region of the hippocampus of male Wistar rats and Wistar audiogenic rats (aged 90 ± 3 days), a strain of inbred animals susceptible to audiogenic seizures. Field excitatory postsynapti...

Purpose The ketogenic diet (KD) has gained popularity due to its ability improve type 2 diabetes, weight loss, antioxidant and anti-inflammatory activity. However, long-term use of the KD might not be safe adverse effects. This study examined effects alone or in combination with Zamzam water (holy for Muslims) on glucose homeostasis, lipid parameters oxidant-antioxidant variables rats. Design/m...

This study was done to highlight the diverse benefits of Citrullus lanatus (egusi melon) seeds with the principal focus on its highly nutritive and calorific values. This makes Citrullus lanatus necessary in diet and in the fight against malnutrition. It also indicated the effect of Citrullus lanatus on Follicle Stimulating Hormone (FSH), Luteinizing hormone (LH) and Testosterone which are resp...

Previous studies have shown that conditioned blocking of taste aversion learning in 3-month-old Wistar rats depends on the hippocampal system integrity. Thus, the aim was to demonstrate that enough connectivity would develop after a graft to support the attention mechanism required for conditioned blocking. In the first experiment, bilateral homotopic grafts of 16-17 day-old hippocampal fetal t...

BACKGROUND Metabolic syndrome can be caused by modification of diet by means of consumption of high carbohydrate and high fat diet such as fructose. AIMS To develop a metabolic syndrome rat model by induction of fructose drinking water (FDW) in male Wistar rats. METHODS Eighteen male Wistar rats were fed with FDW 20% and FDW 25% for a duration of eight weeks. The physiological changes with ...

Pseudomonas aeruginosa exotoxin A (PEA) causes severe hepatotoxicity in experimental animals and is useful in investigations of immune-mediated liver injury. However, strain differences in the sensitivity to PEA-induced hepatotoxicity in rats remains be elucidated. In this study, we determined the severity of PEA-induced hepatotoxicity in six genetically different rat strains. Male LE (Long Eva...