renal ischemia-reperfusion (ir) injury is a common problem in kidney transplantation. there is increasing evidence about the role of the reactive oxygen species (ros) in these injuries and endogenous antioxidants seem to have an important role in decreasing the renal tissue injury. the aim of this study was to investigate the effects of kidney ir on renal antioxidant enzymes activity such as ca...

major proportion of intracellular calcium (ca 2+ ) is achieved through opening of calcium channels present in the plasma membrane which play an important role in regulating neuromuscular coordination and release of neurotransmitters from nerve terminals. blockade of these calcium channels adversely affect contractile process and release of neurotransmitters in majority of the neuromuscular prep...

The quantal hypothesis for the release of neurotransmitters at the chemical synapse has gained wide acceptance since it was first worked out at the motor endplate in frog skeletal muscle in the 1950's. Considering the morphological identification of synaptic vesicles (SVs) at the nerve terminals that appeared to be homogeneous in size, the hypothesis proposed that signal transduction at synapse...

The gastrointestinal motility is regulated by extrinsic and intrinsic neural regulation. Intrinsic neural pathways are controlled by sensory input, inter-neuronal relay and motor output. Enteric motor neurons release many transmitters which affect post-junctional responses. Post-junctional responses can be excitatory and inhibitory depending on neurotransmitters. Excitatory neurotransmitters in...

G protein-coupled receptors (GPCRs) are the largest family of membrane and major drug targets. They play a fundamental role in endocrine system, where they mediate effects several hormones neurotransmitters. As result, alterations GPCR signalling cause disorders such as congenital hypothyroidism or Cushing’s syndrome. My group develops innovative optical methods fluorescence resonance energy tr...

The beneficial effects of exercise on brain function have been demonstrated in animal models and in a growing number of clinical studies on humans. There are multiple mechanisms that account for the brain-enhancing effects of exercise, including neuroinflammation, vascularization, antioxidation, energy adaptation, and regulations on neurotrophic factors and neurotransmitters. Dopamine (DA), nor...

The present study analyzed expressional changes of excitatory neurotransmitters and inhibitory neurotransmitters in the rat corpus striatum after single-use and combined-use diazepam and Chinese herb moschus. The influence of moschus on the central nervous system was analyzed, in particular whether moschus increased penetration of other drugs into the brain. Reverse-phase high-performance liqui...