Western Ontario, London, Ontario, Canada. Received for publication October 28, 1964; revised May 21, 1965. fluence of hormonal stimulation and Nandi (42) empha sized the importance of the milk agent in inducing hy PerPlastic alveolar nodules and eventual tumor. 1\Iice without the milk agent may be infected by ingestion or injection of milk, by injection of semen (5, 38), or by transplantation o...

The mammary gland is a dynamic organ that undergoes structural and functional changes associated with growth, reproduction, and post-menopausal regression. The postnatal transformations of the epithelium and stromal cells of the mammary gland may contribute to its susceptibility to carcinogenesis. The increased cancer incidence in mammary glands of humans and similarly of rodents in association...

Objective- This study refers to the role of ultrasonography in the diagnosis of mammary gland tumor in bitches as a complementary diagnostic method and its ultimate goal is to evaluate the results of mammography with the positive results of ultrasonography. Design- Prospective study. Animals- 12 German Shepherd bitches with swollen mass in the mammary gland region (group I) and 12 h...

Pancreatic cancer mucins have several carbohydrate antigens that are potentially useful in the detection of pancreatic cancers, but little is known about the core polypeptides of pancreatic cancer mucins. In this study, purified mucin from SW1990 pancreatic cancer xenografts was deglycosylated by treatment with hydrogen fluoride to give pancreatic cancer apomucin. Consistent with near-complete ...

OBJECTIVE The mouse mammary tumor virus (MMTV) is the well-established etiological agent of mammary tumors in mice. A series of studies have implicated that a human murine mammary tumor virus-like virus occurs in human breast cancer, but it is unclear whether it has any causal role. METHODS The aim of the present study was to investigate the presence of MMTV env gene-like sequences in a group...

Parity in women is associated with reduced lifetime risk of breast cancer, and hormones of pregnancy [estrogen (E), progesterone (P), human chorionic gonadotropin (hCG)] are implicated. Parity also reduces mammary cancer risk in carcinogen-exposed rats, and administering pregnancy hormones to these animals is similarly effective. Because pregnancy hormones are also able to stimulate cancer grow...

Western Ontario, London, Ontario, Canada. Received for publication October 28, 1964; revised May 21, 1965. fluence of hormonal stimulation and Nandi (42) empha sized the importance of the milk agent in inducing hy PerPlastic alveolar nodules and eventual tumor. 1\Iice without the milk agent may be infected by ingestion or injection of milk, by injection of semen (5, 38), or by transplantation o...

BACKGROUND The study reviews the anticancer properties of natural isoflavones which occur in especially high concentration in soybeans. It considers the suitability of soybean products for clinical trials aiming to reduce the progression of breast cancer. METHODS Evidence is reviewed that plant isoflavones such as genistein show cytostatic activity against human mammary cancer cell lines in v...

Cancer stem cells (CSC) represent a small subpopulation of cells in malignant tumors that possess the unique ability to self-renew, differentiate and resist chemo- and radiotherapy. These cells have been postulated to be the basis for some of the difficulties in treating cancer, and therefore, numerous approaches have been developed to specifically target and eliminate CSC in diverse types of c...

The ACI rat model of 17β-estradiol (E2)-induced mammary cancer has gained wide use in the study of breast cancer etiology, prevention, and genetics. Emca8, a QTL that determines susceptibility to E2-induced mammary cancer, was previously mapped to rat chromosome 5 (RNO5) in an intercross between resistant Brown Norway (BN) and susceptible ACI rats. In this study, a panel of congenic rat strains...