We previously identified and characterized a novel tumor growth inhibitor and a fatty acid-binding protein in human mammary gland and named it the mammary-derived growth inhibitor-related gene (MRG). Here, the effects of MRG on mammary gland differentiation and its interaction with v-3 polyunsaturated fatty acids (v-3 PUFAs) on growth inhibition were investigated. MRG protein expression was ass...

The delivery of copper to mammary gland and milk and the effects of lactation were examined in rats. Traces of (67)Cu/(64)Cu(II) were injected intraperitoneally or intravenously into virgin rats or lactating rats (2-5 days postpartum), and incorporation into blood, milk, and tissues was monitored. In virgin rats, most of the isotope first entered the liver and kidney. In lactating rats, almost ...

We previously identified and characterized a novel tumor growth inhibitor and a fatty acid-binding protein in human mammary gland and named it the mammary-derived growth inhibitor-related gene (MRG). Here, the effects of MRG on mammary gland differentiation and its interaction with v-3 polyunsaturated fatty acids (v-3 PUFAs) on growth inhibition were investigated. MRG protein expression was ass...

The development of the mouse mammary gland occurs postnatally. Hormonal activation of local growth factor pathways stimulates rapid elongation and branching of the rudimentary gland through the fatty stroma. Earlier studies showed that GH is required for mammary gland ductal morphogenesis and that IGF-I mediates this action of GH. In the present study we show that adult IGF-I(m/m) mutant mice e...

ONE of the most interesting natural transformations in carbohydrate metabolism is that occurring in the active mammary gland during the synthesis of the galactose-containing disaccharide, lactose. Rohmann [1919] was able to obtain some evidence of the synthesis of lactose by the action of an extract of the mammary gland upon added sucrose. This investigator, on what now seems inconclusive evide...

Insulin-like growth factors (IGFs) are important survival signals that can protect a range of cell types from apoptosis. Although IGF bioavailability is modulated by high affinity interactions with IGF-binding proteins (IGFBPs), there is currently no experimental evidence that IGFBPs regulate the survival function of IGFs in the mammary gland. We have examined IGFBP expression during mammary gl...

It has been well established that the occurrence of cancer of the mammary gland of certain strains of mice is greatly influenced by a factor which is transmitted to the young via the mother's milk (Bittner, 1936; see also Dmochowski, 1953; Greenstein, 1954). The nature of this 'nmilk factor' is still uncertain. Huseby, Barnum & Bittner (1950) found that a large proportion of the milkfactor acti...

The mammary gland is a highly regenerative organ that can undergo multiple cycles of proliferation, lactation, and involution. Based on the facts that (i) mammary stem/progenitor cells (MaSC) are proposed to be the driving forces behind mammary growth and function and (ii) variation exists between mammalian species with regard to physiological and pathological functioning of this organ, we beli...

PTHrP is necessary for the formation of the embryonic mammary gland and, in its absence, the embryonic mammary bud fails to form the neonatal duct system. In addition, PTHrP is produced by the breast during lactation and contributes to the regulation of maternal calcium homeostasis during milk production. In this study, we examined the role of PTHrP during post-natal mammary development. Using ...

3. Insulin did not alter the inactivity of rat mammary gland slices towards acetate as sole substrate, but in presence of glucose it considerably increased the 14C found in the fatty acids. The incorporation of "IC into the fatty acids of sheep udder slices wasunaffected by insulin both in acetate alone and in acetate plus glucose. 4. Glycerol caused a slight incorporation of acetate carbon int...