BACKGROUND An increasing number of youth are being diagnosed with, and treated for, bipolar disorder (BD). Controversy exists about whether youth with non-episodic irritability and symptoms of attention deficit hyperactivity disorder (ADHD) should be considered to have a developmental presentation of mania. METHOD A selective review of the literature related to this question, along with recom...

OBJECTIVE Despite clear gender differences in the symptoms and course of bipolar affective disorder, studies investigating age at onset by gender have yielded inconsistent results. The authors investigated gender differences in age at onset and incidence of first-episode mania and bipolar disorder in an epidemiological catchment area in southeast London over a 35-year period. METHOD All adult...

PURPOSE OF REVIEW Mood regulation problems, such as severe chronic irritability or short episodes of mania-like symptoms, are common, impairing and a topic of intense recent interest to clinicians, researchers and the Diagnostic and Statistical Manual (DSM)-5 process. Here, we review the most recent findings about these two presentations and discuss the approaches to their treatment. RECENT F...

Clara cell protein (CC16) and transferrin receptor (TfR) have been reported as possible biological markers for major depression and schizophrenia. However, the alternations of plasma TfR and CC16 levels and the influences of numerous clinical variables on them during bipolar mania are not sufficiently described. We investigated the immune function of 36 bipolar I, manic (DSM-IV) patients with Y...

Herpes simplex encephalitis is associated with marked psychological disturbances both in the acute phase and as a chronic sequelae. Mania has been reported as an acute phase manifestation of HSE, but not as long term consequence. Here we report two cases of mania developing as a long term complication of HSE, in the absence of any other predisposing factor. The possible mechanisms underlying th...

Recently, many cases of Fluoxetine induced mania have been reported in the literature. The detailed analysis of these case reports demonstrates that these patients had either positive family history of affective disorder (Lebegne, 1987), past history of affective illness (Settle and Settle, 1984; Lebegne, 1987; Nakra el al., 1989) or were related to high doses of fluoxetine (Chouinard and Stein...

According to the DSM-IV-TR, hypomania in bipolar II disorder (BD II) must not display marked impairment of functioning, compared with mania, and the change in functioning may be increased or decreased without reporting which is more common (1). Because of the marked impairment of functioning criterion, the DSM-IV-TR’s unclear boundary between mania and hypomania can lead to misclassification (t...

SUMMARY Oligodendrogliomas may present with a variety of psychological symptoms but it only rarely presents with mania. The patient described in this case report is a 55-year-old man with a three year history of progressive mania who was initially diagnosed as chronic mania but a subsequent MRI identified a brain tumor. This report highlights the importance of considering differential organic d...

Sleep deprivation is a potentially useful non-pharmacological treatment for depression. A relationship between sleep loss and the onset of mania has been reported, so it is possible that a switch from depression into mania after sleep deprivation might be expected in bipolar depressed patients who are treated with sleep deprivation. In a sample of 206 bipolar depressed treated with three cycles...

The purpose of this cohort study is to shed further light on the potential carcinogenic effect indicated by a Swedish case control study of the 2,4-dichlorophenol and 4-chloro-ortho-cresol based phenoxy herbicides, unlikely to be contaminated with 2,3,7,8-tetrachlorodibenzo-p-dioxin (2,3,7,8-TCDD). In the present study it was the intention to include all persons employed in manufacture of pheno...