C et al. Influence of pre-operative left ventricular contractile reserve on postoperative ejection fraction in low-gradient aortic stenosis. Outcome after aortic valve replacement for low-flow/low-gradient aortic stenosis without contractile reserve on dobutamine stress echocardiography.dictors of outcomes in low-flow, low-gradient aortic stenosis: results of the multi-center TOPAS Study. B-typ...

Introduction Cryopyrin-associated periodic syndrome (CAPS) is a rare systemic, monogenetic inherited autoinflammatory condition caused by NLRP3/CIAS 1 gene mutations encoding for cryopyrin, a major component of the inflammasome, leading to an excessive production of interleukin-1beta (IL-1ß). The clinical picture of genetic variations of the NLRP3 inflammasome is characterized by recurrent epis...

Gahlot N, et al. BMJ Case Rep 2017. doi:10.1136/bcr-2017-221617 DESCRIPTION A 2 year old child presented with low-grade fever, progressive pain and swelling of right leg for the past 3 months. There was no history of injury, chronic cough, respiratory symptoms, weight loss or arthritis. Child’s father had been treated for pulmonary tuberculosis 1 year back. On examination, there was a firm, dif...

1. Kindler T. congenital poikiloderma with traumatic bulla formation and progressive cutaneous atrophy. Br J Dermatol 1954; 66: 104-11. 2. Yazdanfar A, Hashemi B. Kindler syndrome: report of three cases in a family and a brief review. Int J Dermatol 2009; 48:145-52. 3. Penagos H, Jaen M, Sancho MT, Saborio MR, Fallas VG, Siegel DH, et al. Kindler syndrome in Native Americans from Panama: report...

Introduction Vestibular schwannoma (also known as acoustic neuroma) is a benign tumor whose cells are derived from Schwann sheaths, which commonly occurs from the vestibular portion of the eighth cranial nerve. Furthermore, vestibular schwannomas account for ∼8% of intracranial tumors in adults and 80 to 90% of tumors of the cerebellopontine angle. Its symptoms are varied, but what stands out m...

Sarcoidosis is a multisystem disorder of unknown etiology characterized by the presence of non-caseating granulomas in the organs affected. Sarcoid arthropathy is a rare manifestation, and sacroiliitis is an unusual first manifestation of the disorder

A study of X inactivation in 12 female carriers for adrenoleucodystrophy showed no evidence that skewed patterns are related to clinical manifestation. Other possible mechanisms to explain manifestation in females are considered.

Background: Lichen planus (LP) is an idiopathic papulosquamous disorder, which can show cutaneous or mucosal signs. It is caused by a cell mediated immune response to an antigen. A wide range of clinical manifestations has been reported. Objective: To determine the sex and age frequency and clinical presentations of this disease in patients referred to Razi hospital in Tehran. Patients and Meth...

Acute diarrhea is usually mild and self-limited in normally healthy individuals. Further diagnostic evaluation is indicated in patients with severe diarrhea. We present a case of a 46-year-old woman who presented with dehydration and acute renal failure due to acute severe diarrhea. Initial stool study was suggestive of Aeromonas. Further stool test revealed offending bacteria, which led to app...

age of 40 years and is slightly more common in males. The long-term complication of DVT is chronic venous insufficiency resulting in limb oedema, pain and venous ulceration, which pose significant morbidity for the patient. Mortality from DVT is secondary to pulmonary embolism. Pulmonary embolism is an extremely common condition and a leading cause of death in all age groups.Prompt diagnosis an...