Production of recombinant proteins generates a variety of process-related impurities. The multistep manufacturing processes may introduce many potential contaminants into the final pharmaceutical products. These residual impurities and contaminants can potentially impact the protein stability significantly. In this short review, the authors intend to discuss major sources and types of residual ...

Near Net Shape (NNS) manufacturing produces the engineering components closer to its final specification in single stage or minimum number of stages. ADI process technology is one of the NNS manufacturing technologies, currently being followed by the industries for manufacturing of engineering components at competitive price. Austempered Ductile Iron is a new class of engineering material which...

Today's process manufacturers are faced with a volatile economy, intense competition and rising energy/material costs. Improving operational for margin purposes, but also for long term success. Cost reduction and quality/productivity improvement have now become key levers for gaining competitive advantage. Operational excellence is the pursuit of conducting business in a manner that continuousl...

Because of increasing competition and cost pressure, the manufacturing industry is currently undergoing massive changes that are facilitated by the usage of Information Technologies. Two particular aspects are the usage of Business Process Management (BPM) and Cloud technologies concepts in the manufacturing domain. Rapid elasticity is crucial for the enactment of manufacturing processes in the...

Tougher competitive situations have led to increasing attention being paid to customer satisfaction, of which timely and customized services are the key concepts. As the product life cycle becomes shortened, high product quality becomes necessary for survival. Markets become highly diversi® ed and global, and continuous and unexpected change become the key factors for success. The need for a me...

The author describes ACS Inc.'s Pro-LIMS system which integrates laboratory and process procedures. The system has been shown to be an important toolfor quality assurance in the process manufacturing industry.

This paper describes all the manufacturing cell monitoring process particularities, and its several features. It is also done a brief presentation of the data structure used to monitor the manufacturing cell status, and it is explained its achievement and its philosophy by a complete flowchart. 1.Introduction and brief description The monitoring process of the manufacturing cell deals with the ...

Tolerance assignment in product design and process planning (machining) affects both the quality and the cost of the overall product cycle. It is a crucial issue to determine how much the tolerance should be relaxed during the assignment process, since a tight tolerance implies a high manufacturing cost and a loose tolerance results in low manufacturing cost. Hence, during tolerance assignment,...

The premise ofQuality byDesign (QbD) is that the quality of the pharmaceutical product should be based upon the understanding of the biology or the mechanism of action (MOA) and the safety of the molecule [1]. The manufacturing process should then be developed to meet the desired quality attributes of the molecule, hence the concept of “design” of the product quality versus “testing” the produc...

Resistance spot welding is an important manufacturing process in the automotive industry for assembling bodies. The quality and strength of the welds and, by extension, the body is mainly defined by the quality of the weld nuggets. The most effective parameters in this process are sheet material, geometry of electrodes, electrode force, current intensity, welding time and sheet thickness. The p...