The single rate codon model of non-synonymous substitution is ubiquitous in phylogenetic modeling. Indeed, the use of a non-synonymous to synonymous substitution rate ratio parameter has facilitated the interpretation of selection pressure on genomes. Although the single rate model has achieved wide acceptance, we argue that the assumption of a single rate of non-synonymous substitution is biol...

Understanding the origins of localized substitution rate heterogeneity has important implications for identifying functional genomic sequences. Outside of gene regions, the origins of rate heterogeneity remain unclear. Experimental studies establish that chromatin compaction affects rates of both DNA lesion formation and repair. A functional association between chromatin status and 5-methyl-cyt...

Abstract We generalize the disutility of effort function in linear-Constant Absolute Risk Aversion (CARA) pure moral hazard model. assume that agents are heterogeneous ability. Each agent’s ability is observable and treated as a parameter indexes associated with task performed. In opposition to literature (the “traditional” scenario), we find new, “novel” scenario, which high-ability agent may ...

Understanding the correlation between synonymous substitution rate and GC content is essential to decipher the gene evolution. However, it has been controversial on their relationship. We analyzed the GC content and synonymous substitution rate in 1092 paralogues produced by two large-scale duplication events in the rice genome. According to the GC content at the third codon sites (GC3), the pa...

The agriculture sector is highly exposed to climate change and, consequently, to its risks. The climate risk is capable of altering other risks such as asset depletion (damage and loss to assets as a result of extreme climate events), price risks (risk of falling or rising prices) and financial risk (from possible increase of interest rates). Based on the assumption that climate changes indirec...

This paper presents a family of multidimensional poverty indices that measure poverty as a function of the extent and the intensity of poverty. I provide a unique axiomatics from which both extent and intensity of poverty can be derived, as well as the poor be endogenously identified. This axiomatics gives rise to a family of multidimensional indices whose extremal points are the geometric mean...