OBJECTIVES The aim of this study was to evaluate mast cell (MC) density and migration and their association with matrix metalloproteinase (MMP) 9 expression in squamous cell carcinoma (SCC) and actinic cheilitis (AC). STUDY DESIGN Tryptase, c-Kit, and MMP-9 expression was evaluated in 20 cases of SCC, 20 cases of AC, and 7 cases of normal lip (control samples) by immunohistochemistry techniqu...

Mast cells are resident effector cells, which are essential for the elicitation of the allergic response of immediate type. However, the release and significance of different mast cell mediators in the allergic wheal reaction are poorly understood, except for histamine. Therefore, in this study the involvement of mast cell mediators in the allergic prick test wheal induced by cow and bee allerg...

Purpose Our previous study demonstrated significantly more degranulating mast cells (MCs) in choroids from subjects with age-related macular degeneration compared to aged controls. This study examined the immunolocalization of tryptase, the most abundant MC secretory granule-derived serine protease, in aged control eyes and eyes with geographic atrophy (GA). Methods Postmortem human eyes with...

Abstract Hereditary a-tryptasemia (HaT) is a genetic trait defined by elevated serum tryptase caused increased TPSAB1 copy number and associated with multiple phenotypes including pain. CACNA1H encoding the voltage-gated calcium channel Ca V3.2 overlaps locus where partial gain-of-function (GOF) haplotype containing 3 linked variants has been shown to be co-inherited HaT in ~2/3 of individuals....

BACKGROUND Initiated and regulated by mast cells, allergic responses are balanced through an intricate network of positive and negative signals. We have recently shown that the inhibitory receptor CD300a is expressed on human mast cells and modulates a large array of their functions. OBJECTIVE We sought to evaluate CD300a as a negative regulator of allergic inflammation in vivo by means of a ...

OBJECTIVE Recent studies have highlighted the pathogenetic importance of chronic inflammation in cardiovascular disorders such as congestive heart failure and atherosclerosis. Mast cells release a wide variety of immune mediators that may initiate inflammatory responses, whereas endothelial cells (ECs) play a prominent role in the pathogenesis of cardiovascular diseases by secreting cytokines. ...

The mast cell, a potent inflammatory cell type, is widely distributed over several tissues, but particularly prominent at the interface exposed to the environment to act in the first line of defense against pathogens. Upon activation mast cells release granules, which contain a large panel of mediators, including neutral proteases (e.g. chymase and tryptase), cathepsins, heparin, histamine and ...

Idiopathic bronchiolitis obliterans organizing pneumonia (BOOP) is characterized by air space in¬ flammation and fibrosis of unknown origin. The pathogenesis of the inflammatory reaction and fi¬ brosis in fibrotic lung disorders remains unclear; however, recent attention has focused on the po¬ tential role ofthe mast cell in the genesis of fibrosis. To determine whether mast cells are implicate...

OBJECTIVE The role of mast cells as the key effector of allergic inflammation, anaphylactic inflammatory reactions and in the pathogenesis of chronic inflammation, is well-known. The present study is adopted to compare mast cells and inflammatory cells within periapical granuloma and cysts and localize the mast cells and quantify their number in the periapical cysts so as to propose a role of m...