Inbreeding coefficients of artificially bred Ayrshire, Guernsey, Holstein, Jersey, and Brown Swiss cows were calculated from relationships between sires and maternal male ancestors. Percentages of inbred cows and average inbreeding coefficients of inbred cows were: Ayrshire, 26 and 11%; Guernsey, 11 and 4%; Holstein, 31 and 1%; Jersey 23 and 2%; and Brown Swiss, 23 and 2%. Percentages of inbred...

This study is based on 12708 first-parity and 7062 second-parity Yorkshire litters from Swedish nucleus herds; and on 1037 first-parity Yorkshire litters from an experimental herd. Gestation length was analysed together with litter size, piglet mortality and average piglet growth rate. A sire–dam model was used to estimate direct (litter) and maternal (sow) genetic effects. Direct heritability ...

The effects of heterogeneity of variance among herds on dairy sire evaluation were examined. Data consisted of 111,196 first lactation Holstein production records of heifers calving in Ontario between 1978 and 1983. To account for selection, older sires without first crop daughters in the data were treated as fixed effects. Herds were classified into one of nine groups based on their estimated ...

Three methods of sire evaluation were compared empirically--herdmate comparison, least squares, and maximum likelihood. Michigan Dairy Herd Improvement Association Holstein data representing 10,620 first lactation records and 1,003 herd-year groups were analyzed. Forty individual bulls representing three artificial insemination units were evaluated. The rank correlations among herdmate comparis...

This position paper gives an overview of model-based testing and discusses how it might fit into the proposed grand challenge for a

In the framework of the 2015 D3R inaugural grand challenge, blind binding pose and affinity predictions were performed for a set of 180 ligands of the Heat Shock Protein HSP90-α protein, a relevant cancer target. Spectral clustering was used to rapidly identify alternative binding site conformations in publicly available crystallographic HSP90-α structures. Subsequently, multiple docking and sc...