In cycling cells, the rDNAs are expressed from telophase to the end of G2 phase. The early resumption of rDNA transcription at telophase raises the question of the fate of the rDNA transcription machinery during mitosis. At the beginning of mitosis, rDNA transcription is arrested, and the rDNAs are clustered in specific chromosomal sites, the nucleolar organizer regions (NOR). In human cells, w...

Filaments which form either between or around active regions (ARs) are called intermediate filaments. In spite of various theoretical studies, the origin of the chirality of filaments is still uncovered. We investigated how intermediate filaments are related to their associated ARs, especially from the point of view of magnetic helicity and the orientation of polarity inversion lines (PILs). Th...

Identical genes in the same cellular environment are sometimes expressed differently. In some cases, including the immunoglobulin heavy chain (IgH) locus, this type of differential gene expression has been related to the absence of a transcriptional enhancer. To gain additional information on the role of the IgH enhancer, we examined expression driven by enhancers that were merely weakened, rat...

The newly-commissioned University of New South Wales Infrared Fabry-Perot (UNSWIRF) has been used to image molecular hydrogen emission at 2.12 and 2.25 m in the reeection nebula Parsamyan 18. P 18 is known to exhibit low values of the (1 ? 0)=(2 ? 1) S(1) ratio suggestive of UV-pumped uorescence rather than thermal excitation by shocks. Our line ratio mapping reveals the full extent of this uor...

We have determined the nucleotide sequences of two regions within the A+T-rich region of mitochondrial DNA (mtDNA) in the siIII type of Drosophila simulans and the maI type of D. mauritiana. The sequences of the two regions in siIII and maI are almost identical. The sequences include elements corresponding to the type I and type II repeats elements and the T-stretches as reported in D. melanoga...

Innate immune responses against viral infection, especially the induction of type I interferon, are critical for limiting the replication of the virus. Although it has been shown that DNA can induce type I interferon, to date no natural DNA ligand of a virus that induces type I interferon has been described. Here we screened the genome of murine gammaherpesvirus 68 with mutations at various gen...

AIM A database based on distributional records of Eurasian Zephyrus hairstreaks (Lepidoptera: Lycaenidae: Theclini) was compiled to analyse their areas of endemism (AoEs), species richness and distribution patterns, to explore their locations of past glacial refugia and dispersal routes. METHODS Over 2000 Zephyrus hairstreaks occurrences are analysed using the NDM/VNDM algorithm, for the reco...

Recent experiments have shown that the cellular E2F transcription factor is found in complexes with cellular proteins and that one such complex contains the cyclin-A protein. Isolation of a cellular activity, which we term E2F-BF, can reconstitute the E2F-cyclin-A complex and has permitted a more detailed analysis of the mechanism of E1A dissociation. Through the analysis of a series of E1A mut...

In this study, we randomly sampled Drosophila melanogaster from Japanese and Kenyan natural populations. We sequenced duplicated (proximal and distal) Amy gene regions to test whether the patterns of polymorphism were consistent with neutral molecular evolution. F(st) between the two geographically distant populations, estimated from Amy gene regions, was 0.084, smaller than reported values for...

We propose a new automatic image segmentation method. Color edges in an image are first obtained automatically by combining an improved isotropic edge detector and a fast entropic thresholding technique. After the obtained color edges have provided the major geometric structures in an image, the centroids between these adjacent edge regions are taken as the initial seeds for seeded region growi...