This study aimed to improve the dissolution rate of aceclofenac and release drug in a controlled manner over period 24 hours. Matrix tablets were prepared by direct compression method, using hydrophilic polymers (HPMC/guar gum). wet granulation method different Tablets evaluated for vitro profile phosphate buffer with pH 6.8 (without enzymes). The thickness hardness 3.23 ± 0.035 3.28 0.008 mm 3...

The aim of study is to develop colon targeted system for metronidazole using guar gum and xanthan gum. Matrix formulations containing various proportions of guar gum and xanthan gum were prepared by wet granulation technique. Later on, multilayer tablets were prepared by using 50 mg and 100 mg of guar gum as release controlling layer on either side of (M5) matrix tablets of metronidazole. The i...

The aim was to determine the release-modifying effect of carboxymethyl xyloglucan for oral drug delivery. Sustained release matrix tablets of tramadol HCl were prepared by wet granulation method using carboxymethyl xyloglucan as matrix forming polymer. HPMC K100M was used in a small amount to control the burst effect which is most commonly seen with natural hydrophilic polymers. A simplex centr...

The main objective of this research investigational studies is to formulate floating matrix tablets glimipride by applying simplex centroid design for optimization technique and direct compression method. Centroid configuration was drilled as an enhancement strategy adjusting the amount three components all while holding back their total concentration constant. Ingredients HPMC K15m, Kappa-carr...

Aim: The present investigation highlights the formulation and evaluation of matrix tablets of propranolol hydrochloride (HCl) using a natural polymer, is gum kondagogu. Materials and Methods: Wet granulation method was used for the preparation of matrix tablets of propranolol HCl using varying proportions of natural polymer as a release retardant, Avicel pH 102 as diluent, talc and magnesium st...