Stressful life events elicit hypothalamic-pituitary-adrenal (HPA) axis activation, which may alter psychological states or behavioral routines. Therefore, the current study focused on the HPA axis response to better understand such manifestations in female prairie voles (Microtus ochrogaster). In Experiment 1, females were stressed for 1 h via one of the four stressors: exposure to a novel envi...

The Anxiety disorders are considering as serious problems in our society life like family environment, school and work functioning. They increase the risk of other psychiatric pathologies, including depression, drug alcohol abuse incidence suicide. For ameliorate this situation, anxiolytic hypnotic substances benzodiazepines, barbiturates their relatives compounds very regularly prescribed. How...

In this paper we consider the dimensions of mobile Energy and Power Management (EPM), outline an EPM design, and elaborate holistic EPM opportunities for battery-operated mobile devices. We argue that a holistic EPM design can offer significant increases for battery lifetime. Our argumentation is based on a number of cases that illustrate how energy consumption can be reduced by opportunistical...

The amygdala, medial hypothalamus, dorsal periaqueductal gray (dPAG), superior and inferior colliculus together constitutes the encephalic aversion system which has been considered the main neural substrate for the integration of unconditioned aversive behavioral states. Within the amygdala the basolateral nucleus (BLA) is thought to act as a filter for innate and learned aversive information t...

A number of confounding factors are believed to affect both basal rodent behaviour and responsivity to psychotropic drugs. To date, few detailed comparative assessments of these confounds have been made. This thesis examined three such factors, namely, housing conditions, i.e. isolation (IC) and environmental enrichment (EE) compared to standard group conditions (SC); sex (males compared to fem...

BACKGROUND AND PURPOSE Mice with functional ablation of substance P-preferring neurokinin-1 receptors (NK1R-/- mice) display behavioural abnormalities resembling those in attention deficit hyperactivity disorder (ADHD). Here, we investigated whether the ADHD treatment, guanfacine, alleviated the hyperactivity and impulsivity/inattention displayed by NK1R-/- mice in the light/dark exploration bo...

Citation: Nyuyki KD, Cluny NL, Swain MG, Sharkey KA and Pittman QJ (2018) Altered Brain Excitability and Increased Anxiety in Mice With Experimental Colitis: Consideration of Hyperalgesia and Sex Differences. Front. Behav. Neurosci. 12:58. doi: 10.3389/fnbeh.2018.00058 Crohn’s disease (CD) and ulcerative colitis (UC) are incurable lifelong inflammatory bowel diseases (IBD) with a rising worldwi...

Discontinuation of drug intake in cocaine abusers commonly produces a variety of adverse withdrawal symptoms among which anxiety and depression-related behavior are prevailing during the initial period of abstinence. The aim of this study was to provide further insight into the neurobiological dysregulations that might contribute to these pathological states. Rats were treated with cocaine or s...

OBJECTIVES The extract of Lippia citriodora and its main component, verbascoside, are known for their hypnotic effects in traditional medicine. In this study, the anxiolytic and hypnotic effects of L. citriodora leave extracts and verbascoside were evaluated in mice. MATERIALS AND METHODS Animals were divided into 11 groups of six mice each. Group I received normal saline, Group II received D...