Although studies have shown that prolactin (Prl) and metoclopramide (Mcp) administration restores the depressed cell-mediated immune functions after hemorrhage, the underlying mechanism responsible for the immunostimulatory effects of Mcp remains unknown. We hypothesized that Mcp improves immune responses by upregulating the secretion of Prl. To test this hypothesis, male C3H/HeN mice were subj...

Chen, Xi-Lin, Qiang Zhang, Ruozhi Zhao, and Russell M. Medford. Superoxide, H2O2, and iron are required for TNFinduced MCP-1 gene expression in endothelial cells: role of Rac1 and NADPH oxidase. Am J Physiol Heart Circ Physiol 286: H1001–H1007, 2004. First published October 30, 2003; 10.1152/ajpheart.00716. 2003.—Reactive oxygen species (ROS) play an important but not yet fully defined role in ...

Infection by human T-cell leukemia virus type (HTLV) I leads to adult T-cell leukemia and is also associated with the neurodegenerative disease HTLV-I-associated myelopathy/tropical spastic paraparesis. Leukocytes are attracted to sites of inflammation by chemokines. One such chemokine is monocyte chemoattractant protein (MCP)-1, a member of the C-C subfamily of chemokines. We investigated whet...

Monocyte chemoattractant protein (MCP)-1 plays a key role in atherosclerosis and inflammation associated with visceral adiposity by inducing mononuclear cell migration. Evidence shows that mouse peritoneal macrophages (MPM) express a 12-lipoxygenase (12/15-LO) that has been clearly linked to accelerated atherosclerosis in mouse models and increased monocyte endothelial interactions in both rode...

In order to develop a long-lifetime MCP-PMT under high rates of circumstance, we investigated the degradation of the quantum efficiency (QE) of PMT’s with a multialkali photocathode. We found that not only positive ions, but also neutral residual gases would damage the photocathode resulting in an enhancement of the work function; their countermeasures were established in newly manufactured squ...

To examine the lifetime of a micro-channel plate photo-multiplier tube, we measured its basic performance, gain, quantum efficiency (QE), transit time spread and dark counts as a function of the integrated amount of irradiated photons up to 2:8 10 photons=cm, corresponding to a 14-year time duration under supposed super-KEKB experimental conditions. The effect of the ion-feedback protection lay...

The classical PERT approach uses the path with the largest expected duration as the critical path to estimate the probability of completing a network by a given deadline. However, in general, such a path is not the most critical path (MCP) and does not have the smallest estimate for the probability of completion time. The main idea of this paper is derived from the domination structure between ...

OBJECTIVE To determine serum levels of monocyte chemotactic protein-3 (MCP-3) and its clinical associations in patients with systemic sclerosis (SSc). METHODS Serum MCP-3 levels from 69 patients with SSc were examined by ELISA. RESULTS Serum MCP-3 levels were raised in patients with SSc (n = 69) compared with healthy controls (n = 28). Patients with diffuse cutaneous SSc (n = 36) had higher...

Monocytes/macrophages are critical early innate immune responders during murine CMV (MCMV) infection. It has been established that inflammatory monocyte/macrophages are released from the bone marrow and into the peripheral blood before entry into infected tissue sites. We previously reported a role for IFN-alpha/beta in promotion of CCR2-mediated recruitment of monocyte/macrophages into the liv...

OBJECTIVE The dynamic expressions of monocyte chemo attractant protein-1 (MCP-1) and CC chamomile receptor 2 (CCR2) after balloon injury and their effects in intimal proliferation were discussed. In this study, the expression of MCP-1 and its receptor during the intimal proliferation in rat artery after balloon injury were studied. METHODS Using the model of balloon injury of rats' arteries, ...