glimepiride/metformin(2/500mg) is an oral antihyperglycemic agent for the treatment of type 2 diabetes. a generic glimepiride/metformin(2/500mg) fixed-dose combination(fdc) tablet was developed recently. this study was designed to collect data for submission to korean regulatory authorities to allow the marketing of the test formulation. we evaluated the comparative bioavailability and tolerabi...

We show that the efficient frontier for a portfolio in which short positions precisely offset the long ones is composed of a pair of straight lines through the origin of the risk-return plane. This unique but important case has been overlooked because the original formulation of the mean-variance model by Markowitz as well as all its subsequent elaborations have implicitly excluded it by using ...

CONTEXT Polymeric carrier systems of paclitaxel (PCT) offer advantages over only available formulation Taxol® in terms of enhancing therapeutic efficacy and eliminating adverse effects. OBJECTIVE The objective of the present study was to prepare poly (lactic-co-glycolic acid) nanoparticles containing PCT using emulsion solvent evaporation technique. METHODS Critical factors involved in the ...

The Black-Litterman (BL) model is a widely used asset allocation model in the financial industry. In this paper, we provide a new perspective. The key insight is to replace the statistical framework in the original approach with ideas from inverse optimization. This insight allows us to significantly expand the scope and applicability of the BL model. We provide a richer formulation that, unlik...

BACKGROUND The variable success of topical minoxidil in the treatment of androgenic alopecia has led to the hypothesis that other pathways could mediate this form of hair loss, including infection and/or microinflammation of the hair follicles. In this study, we prepared a multimodal microemulsion comprising minoxidil (a dihydrotestosterone antagonist), diclofenac (a nonsteroidal anti-inflammat...

This paper introduces an algorithm to determine near-optimal control laws for Markov Decision Processes with a risk-sensitive criterion. Both the fully observed and the partially observed settings are considered, for nite and innnite horizon formulations. Dynamic programming equations are introduced which characterize the value function for the partially observed, innnite horizon , discounted c...

OBJECTIVE Subcutaneous (SC) abatacept (ABA) is comparable to intravenous (IV) formulation in terms of efficacy and safety profile. Our work analyzed the switch to SC formulation from IV administration in patients with rheumatoid arthritis. METHODS Fifty-one patients treated with SC ABA were included. Clinical data were obtained from clinical charts. RESULTS Fourteen patients relapsed and ne...

Interstitial lung disease (ILD) is a serious and potentially fatal adverse event in lung cancer therapy. Nanoparticle albumin-bound paclitaxel (nab-PTX) is a novel, solvent-free formulation of paclitaxel (PTX). Although the incidence of nab-PTX-induced ILD is not clear, it is generally considered that this formulation presents a similar risk of developing ILD as PTX. Here, we report 3 patients ...

Human exposure to mechanical vibration may represent a significant risk factor for exposed workers in the agricultural sector, with particular reference to the operators driving tractors. Also noise in agriculture is one of the risk factors to be taken into account for the evaluation of workers health and safety. In particular, one of the major sources of discomfort for the workers operating a ...