BACKGROUND Increases in measles antibodies without rash-illnesses have been documented in previously vaccinated children exposed to measles cases. The phenomenon has been incompletely evaluated in young unvaccinated infants with immunity of maternal origin. METHODS Monthly cohorts of newborns were prospectively randomized to vaccine and placebo control groups during a trial of high-titre vacc...

Measles is the most important cause of vaccine-preventable death in the world. In 1998, there were an estimated 30 million measles cases and 880,000 measles-associated deaths worldwide with 85 per cent of deaths occurring in Africa and South East Asia. 1 In recent years a dramatic reduction in measles incidence and the elimination of endemic measles transmission has been achieved in a number of...

measles, mumps and rubella are viral infectious diseases that may result in serious complications. since the production of vaccines, the number of cases of these diseases has been dropped. nevertheless, these infectious diseases are still one of the major health problems in developing countries. in this study, in order to evaluate the protective responses against measles, mumps and rubella, the...

background: in iran, despite the use of vaccine since 1976, we are still having local epidemics especially in the children aged 15-20 years old. since 1996, the yearly epidemics of measles have been reported in these groups in sistan- baluchestan province, south east of iran. the present study was conducted to determinate the level of immunity in this target population in zahedan. methods: a to...

In 2013, the 66th session of the Regional Committee of the World Health Organization (WHO) South-East Asia Region adopted the goal of measles elimination and rubella and congenital rubella syndrome control by 2020 after rigorous prior consultations. The recommended strategies include 1) achieving and maintaining ≥95% coverage with 2 doses of measles- and rubella-containing vaccine in every dist...

Human antibody response to measles vaccine is highly variable in the population. Host genes contribute to inter-individual antibody response variation. The killer cell immunoglobulin-like receptors (KIR) are recognized to interact with HLA molecules and possibly influence humoral immune response to viral antigens. To expand on and improve our previous work with HLA genes, and to explore the gen...

Dear Editor, I read the paper “mass measles vaccination campaign in Aila Cyclone-affected areas of West Bengal, India” by Malik and colleagues published in the December, 2011 issue of IJMS. The paper described a program of mass measles vaccination that was a good experience for health authorities.1 However, some issues should be considered in health policies for the prevention of measles. Measl...

OBJECTIVE In February 2008, we alerted the Advisory Committee on Immunization Practices to preliminary evidence of a twofold increased risk of febrile seizures after the combination measles-mumps-rubella-varicella (MMRV) vaccine when compared with separate measles-mumps-rubella (MMR) and varicella vaccines. Now with data on twice as many vaccine recipients, our goal was to reexamine seizure ris...

This phase III clinical trial was conducted to evaluate the immunogenicity and safety of the single-dose and multi-dose formulations of a novel MMR vaccine (live, freeze-dried) developed by M/s Cadila Healthcare Limited, India (Cadila MMR vaccine), containing the Hoshino mumps strain, compared to that of an existing MMR vaccine (live, freeze-dried) developed by M/s Serum Institute of India Limi...

In 2010, the World Health Assembly established three milestones toward global measles eradication to be reached by 2015: 1) increase routine coverage with the first dose of measles-containing vaccine (MCV1) for children aged 1 year to ≥90% nationally and ≥80% in every district, 2) reduce and maintain annual measles incidence at <5 cases per million, and 3) reduce measles mortality by 95% from t...