The goal of regenerative periodontal therapy is the reconstitution of the lost periodontal structures (i.e. the new formation of root cementum, periodontal ligament and alveolar bone). Results from basic research have pointed to the important role of the enamel matrix protein derivative (EMD) in the periodontal wound healing. Histological results from animal and human studies have shown that tr...

Vascular architecture in the periodontal ligament of hamster incisors was investigated by use of vascular casts under a scanning electron microscope (SEM). In addition to ordinary nutrient blood vessels, anastomosing vessels of large caliber developed, surrounding the incisor. From their characteristic configuration, these vessels were regarded as "sinusoids". The plexus of sinusoidal vessels w...

Background: Primary tooth impaction is quite rare during the development of primary dentition. Various factors contribute to the impaction of a deciduous tooth, including anklyosis, congenitally missing permanent teeth, defects in the periodontal membrane, trauma, injury of the periodontal ligament, precocious eruption of the first permanent molar, defective eruptive force, or a combination of ...

1 attachment, which is lost during disease. This type of regeneration is described by the term 'New attachment'. New attachment is the embedding of new periodontal ligament fibres on to new cementum previously denuded by the periodontal disease. Factors interfering with new attachment are plaque, calculus, infected cementum and alterations in mineral density and composition of root. These obsta...

Cementum was first described by Denton GB in 1835 as a calcified, avascular mesenchymal tissue that covers the entire root surface. It approximately comprises of 50% of hydroxyappetite and 50% of organic matrix which consist of non collagenous and collagenous proteins. Protein extract of mature cementum promotes cell attachment, migration and stimulates protein synthesis of gingival fibroblast ...

It is challenging to completely and predictably regenerate the missing periodontal tissues caused by trauma or disease. To periodontium, there a need consider several aspects that co-occur with development. This study provides an overview of most up-to-date investigations on characteristics immunomodulatory features Periodontal Ligament Stem Cells (PDLSCs) recent interventions performed using t...

Periodontal regeneration represents the ultimate goal of periodontal therapy. The current regenerative techniques have limited success rates especially in advanced periodontal defects. Currently the research is focused on novel cell-based approaches for periodontal regeneration to overcome the limitations of existing treatment. The human clinical trial on stem cells based periodontal regenerati...