This study examined the effects of radial confinement and passive axial compression-induced vertical confinement, on the biomechanical, biochemical, and histological properties of self-assembled chondrocyte constructs. The self-assembled constructs, engineered without the use of an exogenous scaffold, exhibited significant increases in stiffness in the direction orthogonal to that of the confin...

Cartilage tissue is a nanostructured tissue which is notoriously hard to regenerate due to its extremely poor inherent regenerative capacity and complex stratified architecture. Current treatment methods are highly invasive and may have many complications. Thus, the goal of this work is to use nanomaterials and nano/microfabrication methods to create novel biologically inspired tissue engineere...

OBJECTIVE The composition of articular cartilage changes with progression of osteoarthritis. Since compositional changes are associated with changes in the mechanical properties of the tissue, they are relevant for understanding how mechanical loading induces progression. The objective of this study is to present a computational model of articular cartilage which enables to study the interactio...

Despite continuous progress toward tissue engineering of functional articular cartilage, significant challenges still remain. Advances in morphogens, stem cells, and scaffolds have resulted in enhancement of the bulk mechanical properties of engineered constructs, but little attention has been paid to the surface mechanical properties. In the near future, engineered tissues will be able to with...

Cartilage matrix mechanical function is largely determined by interactions between the collagen fibrillar network and the proteoglycan gel. Although the molecular physics of these matrix constituents have been characterized and modern imaging methods are capable of localized measurement of molecular densities and orientation distributions, theoretical tools for using this information for predic...

Tissue-engineering (TE) efforts for ear reconstruction often fail due to mechanical incompetency. It is therefore key for successful auricular cartilage (AUC) TE to ensure functional competency, that is, to mimic the mechanical properties of the native ear tissue. A review of past attempts to engineer AUC shows unsatisfactory functional outcomes with various cell-seeded biodegradable polymeric ...

BACKGROUND This article provides the rationale and methodology, of the first randomised controlled trial to our knowledge designed to assess the efficacy of progressive resistance training on cartilage morphology in women with knee osteoarthritis.Development and progression of osteoarthritis is multifactorial, with obesity, quadriceps weakness, joint malalignment, and abnormal mechanical joint ...

in this work, leather fibers were employed as a component of elastomeric compounds based on nbr, cr and epdm and studied were made on their effects upon curing characteristics and mechanical properties of the prepared compounds. evaluation of curing characteristics of the compounds demonstrated that leather fibers have no considerable effect on initial viscosity and curing time of the compounds...

Articular cartilage is exquisitely sensitive to mechanical loading, one of the most important external factors that regulates its development, integrity and long-term maintenance. Cartilage undergoes degradation by its misuse or overuse. In this review, we elaborate on this role and discuss the application of mechanical stress on chondrocytes and mesenchymal stem cells in order to foster chondr...