Mechanical stress has detrimental effects on cartilaginous endplate chondrocytes due to apoptosis in vivo and in vitro. In this study, we investigated the possible apoptosis signaling pathways induced by mechanical stress in cultured rat cervical endplate chondrocytes. Static mechanical load significantly reduced cell viability in a time- and load-dependent manner, as demonstrated by the Cell C...

Complete reconstruction of damaged periodontal pockets, particularly regeneration of periodontal ligament (PDL) has been a significant challenge in dentistry. Tissue engineering approach utilizing PDL stem cells and scaffolding matrices offers great opportunity to this, and applying physical and mechanical cues mimicking native tissue conditions are of special importance. Here we approach to re...

The ability of immune cells to migrate within narrow and crowded spaces is a critical feature involved in various physiological processes from immune response to metastasis. Several in-vitro techniques have been developed so far to study the behaviour of migrating cells, the most recent being based on the fabrication of microchannels within which cells move. To address the question of the mecha...

Physical disturbance of plants or plant parts results in a mechanical stress response from the plant. Mechanical stress applied naturally or under controlled conditions inhibits growth in mass and dimensions of major plant parts. Wind and precipitation are important natural sources of mechanical stress. Under field conditions, cultivated plants experience these natural mechanical stresses plus ...

In this paper a composite plate with similar unidirectional fibers is considered. Assuming orthotropic structure, theory of elasticity is used for investigating the stress concentration. Also, complex variable functions are utilized for solving the plane stress problems. Then the effective characteristics of this plate are studied numerically by using ANSYS software. In this research a volume e...

due to the existence of fibrous materials such as plastic fragments, the strength anisotropy of municipal solid waste (msw) materials is the main source of differences between their mechanical response in direct shear and triaxial apparatus. as an extension of earlier research on the mechanical behavior of msw using a large traixail apparatus, results presented in shariatmadari et al. [1] and k...

Quantitative Accelerated Life Testing (QALT) is a solution for assessing thereliability of Micro Electro Mechanical Systems (MEMS). A procedure for QALT is shownin this paper and an attempt to assess the reliability level for a batch of MEMSaccelerometers is reported. The testing plan is application-driven and contains combinedtests: thermal (high temperature) and mechanical stress. Two variant...

BACKGROUND Compressive mechanical stress produced during growth in a confining matrix limits the size of tumor spheroids, but little is known about the dynamics of stress accumulation, how the stress affects cancer cell phenotype, or the molecular pathways involved. METHODOLOGY/PRINCIPAL FINDINGS We co-embedded single cancer cells with fluorescent micro-beads in agarose gels and, using confoc...

BACKGROUND Mechanical stress rapidly induces ΔFosB expression in osteoblasts, which binds to interleukin (IL)-11 gene promoter to enhance IL-11 expression, and IL-11 enhances osteoblast differentiation. Because bone morphogenetic proteins (BMPs) also stimulate IL-11 expression in osteoblasts, there is a possibility that BMP-Smad signaling is involved in the enhancement of osteoblast differentia...