Despite the widespread use of barbiturates and their clear potential for abuse, little is known of their neurochemical mechanisms of action. Our purpose is to review the neurochemical effects of acute and chronic barbiturate administration, with particular emphasis on the relationship between neurochemical changes and the development of tolerance and dependence. The electrophysiological effects...

previous, intravenous immunoglobulin (ivig) has been used for treatment of patients with immunodeficiency. however, recent studies have shown that ivig is a suitable approach for treatment of inflammatory and autoimmune diseases. although the exact mechanism of ivig action is not well known, recent findings have demonstrated that ivig impacts on expression and function of fc receptors of immuno...

Cariprazine is a new therapeutic agent recently approved for the treatment of both schizophrenia and manic or mixed episodes associated with bipolar disorder, and is under investigation for the treatment of both bipolar depression and major depressive disorder.

Psicofuranine is a new antibiotic which was first described by Schroeder and Hoeksema (1959), Eble et al. (1959), and Vavra et al. (1959). It has good antibacterial activity in vivo (Lewis et al., 1959) and antitumor activity (Evans and Gray, 1959), but it shows no activity in vitro when assayed by conventional methods. The activity in vitro was demonstrated using the special media and assay te...

This paper is a summary of studies over the past few years that pertain to animal neurotoxins. These toxins are found throughout the animal kingdom. Homologies exist in the structures of these poisons within classes and point to conservation of active sites throughout evolution. In the case of the peptides, invariant amino acids may be involved in the active site, be essential for maintaining t...

Drugs to reduce anxiety have been used by human beings for thousands of years. One of the first anxiolytics and one that continues to be used by humans is ethanol. A detailed description of ethanol’s action may be found in Chapter 100. A number of other drugs including the barbiturates and the carbamates (meprobamate) were used in the first half of the 20th century and some continue to be used ...