the effects of methanolic extract and leaf powder of artemisia annua were studied on performance, cellular and humoral immunity in 240 cobb broiler chicks in a completely randomized design. control group did not receive any treatment. the chicks in the second and third groups were fed with feed which contained 2000 and 4000 ppm plant extract in diet and in the groups 4, 5 and 6 chicks received ...

objectives: the aim of the present study was to investigate immunotoxic effect of safranal (saf), a main component of crocus sativus essential oil, using balb/c mice. materials and methods: saf was administered intraperitoneally at doses of 0.1, 0.5 and 1 ml/kg for 3 weeks. hystopathological examination of spleen and bone marrow, cellularity of spleen, delayed type of hypersensitivity (dth) res...

A central question in tumour immunology is whether a tumour-specific immune response is capable of controlling tumour progression in cancer patients. Although several animal models have established the role of tumour-specific CD4+ helper and CD8+ cytotoxic T cells in antitumour immunity, a definitive role for these cells in tumour-specific immunity in patients with cancer has yet to be shown. I...

thirty seven randomly selected patients suffering from multiple s c l e r os i s (ms) (17 males and 20 females)and 30 healthy control subjects were studied for the lymphocyte subpopulations and ce l l -medi a t e d immunity.we obs e r ved a decrease of the total t-cells and an increase of a ctive t-lymphocytes and b ce l l s , in ms p at i ent s as compared t o normal controls. the inability of...

cell-mediated immune (cmi) s t a t us and sub- popul at i ons o f pe r ipheral b l ood lymphocytes were investigated in one hundre d volunt a ry blood donors who were car r ier s of ag • he s a signi f i c ant decr e ase of t otal t-cells observed in hb ag carri e rs as compared t o normal controls. the percens t age o f active t-cells a nd b-lymphocytes did not d i f f e r signi f icant ly bet...

for demonstration of cell-mediated immunity and its role in the process of dermatophytosis, 98 patients with acute dermatophytosis (group i) and 131 chronic dermatophytosis patients (group 2) were chosen. in ail patients, lymphocyte transfonnation and skin test were used. 96 members of group i (98%) had positive delayed-type hypersensitivity (dth) responses to trichophytin, whereas only 43 subj...

Dengue vaccine development has made significant strides, but a better understanding of how vaccine-induced immune responses correlate with vaccine efficacy can greatly accelerate development, testing, and deployment as well as ameliorate potential risks and safety concerns. Advances in basic immunology knowledge and techniques have already improved our understanding of cell-mediated immunity of...

Context: Different factors such as the site of infection, etiological agent, and immune system can modify antifungal response host. Differences in Sporothrix schenckii strains’ virulence host’s competency may be involved development sporotrichosis. Nevertheless, mechanisms related to disease’s progression remain not fully elucidated. Nowadays, no model outweighs usefulness mice biological studi...

Edwardsiella tarda is an intracellular pathogen that causes edwardsiellosis in fish. Although cell-mediated immunity and innate immunity play a major role in protection against intracellular bacterial infection in mammals, their importance in protecting fish against E. tarda infection remain unclear. In this study, we examined cell-mediated and humoral immune responses in ginbuna crucian carp (...

Type I Interferon-mediated innate immunity against Flaviviridae, such as Hepatitis C virus (HCV) and Dengue virus (DENV), involves TLR3, RIG-I-like receptor (RLR) and JAK-STAT signal pathways. Asunaprevir is a newly developed HCV protease inhibitor for HCV treatment. Whether, asunaprevir activates innate immunity to restrict viral infection is unclear. Thus, this study investigates the effect o...