نتایج جستجو برای: medicinal chemistry
تعداد نتایج: 143302 فیلتر نتایج به سال:
A large-scale statistical analysis of hit rates of extensively assayed compounds is presented to provide a basis for a further assessment of assay interference potential and multi-target activities. A special feature of this investigation has been the inclusion of compound series information in activity analysis and the characterization of analog series using different parameters derived from a...
The aim of scaffold hopping is to discover structurally novel compounds starting from known active compounds by modifying the central core structure of the molecule. Scaffold hopping is a central task of modern medicinal chemistry requiring a multitude of techniques, which are discussed in this article. Their application has led to several molecules with chemically completely different core str...
Recent Developments in Bisintercalator Natural Products Olga E. Zolova, Ahmed S. A. Mady, Sylvie Garneau-Tsodikova 1 Life Sciences Institute, University of Michigan, 210 Washtenaw Ave., Ann Arbor, MI 48109-2216 2 Department of Pharmaceutical Sciences, Utrecht University, Netherlands 3 Department of Medicinal Chemistry, University of Michigan, Ann Arbor, MI 48109 4 Chemical Biology Doctoral Prog...
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